Results 21 to 30 of about 42,032 (196)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Logics of Finite Hankel Rank

, 2015
We discuss the Feferman-Vaught Theorem in the setting of abstract model theory for finite structures. We look at sum-like and product-like binary operations on finite structures and their Hankel matrices.
A Durand, B Courcelle, B Godlin, B Mahr, CC Chang, E Grädel, G Kreisel, H-D Ebbinghaus, J Barwise, JA Makowsky, JA Makowsky, JA Makowsky, JA Makowsky, JA Makowsky, JA Makowsky, JW Carlyle, KJ Barwise, KJ Compton, L Lovász, M Freedman, N Immerman, P Lindström, P Lindström, S Feferman, S Feferman, S Feferman, S Feferman, S Feferman, S Shelah, Y Gurevich   +29 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

On the topological classification of binary trees using the Horton-Strahler index

, 2001
The Horton-Strahler (HS) index $r=\max{(i,j)}+\delta_{i,j}$ has been shown to be relevant to a number of physical (such at diffusion limited aggregation) geological (river networks), biological (pulmonary arteries, blood vessels, various species of trees)
A. Cayley, A.-L. Barabási, A.N. Strahler, A.P. Ershov, E. Ben-Naim, E.A. Bender, G. Pólya, H. Harrary, I.H.M. Etherington, J. Vannimenus, J.H.M. Wedderburn, J.S. Smart, J.W. Moon, P. Flajolet, P. Nogueira, P.L. Erdős, R. Otter, R.E. Horton, S.H. Strogatz, T.C. Halsey, W.Y.C. Chen, Z. Toroczkai, Zoltán Toroczkai   +22 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Innovative Method of the Power Analysis [PDF]

, 2013
This paper describes an innovative method of the power analysis which presents the typical example of successful attacks against trusted cryptographic devices such as RFID (Radio-Frequency IDentifications) and contact smart cards.
Martinasek, Z., Zeman, V.
core   +1 more source

SAWdoubler: a program for counting self-avoiding walks

, 2012
This article presents SAWdoubler, a package for counting the total number Z(N) of self-avoiding walks (SAWs) on a regular lattice by the length-doubling method, of which the basic concept has been published previously by us.
Barkema, Gerard T., Bisseling, Rob H., Schram, Raoul D.   +2 more
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source