Results 161 to 170 of about 14,922,818 (371)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

The Finite Difference Methods for Fitz Hugh-Nagumo Equation

, 2015
Iosr Journals, Saad A. Manaa, Fadhil H. Easif, Aveen S. Faris   +3 more
openalex   +1 more source

Existence of solutions for a class of nonlinear fractional difference equations of the Riemann–Liouville type [PDF]

, 2022
Pshtiwan Othman Mohammed, H. M. Srivastava, Juan L. G. Guirao, Y. S. Hamed   +3 more
openalex   +1 more source

Global dynamics of certain homogeneous second-order quadratic fractional difference equation. [PDF]

ScientificWorldJournal, 2013
Garić-Demirović M, Kulenović MR, Nurkanović M.   +2 more
europepmc   +1 more source

Resonances in a Coupled Cavity Consisting of Equally-spaced Additional Cavities : Calculation of Natural Frequencies and Modes by Using a Difference Equation

, 1986
Katsuyoshi Nagayasu
openalex   +2 more sources

An energy stable fourth order finite difference scheme for the Cahn-Hilliard equation [PDF]

Journal of Computational and Applied Mathematics, 2017
Kelong Cheng, Wenqiang Feng, Cheng Wang, S. Wise   +3 more
semanticscholar   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

A new difference scheme for the time fractional diffusion equation [PDF]

Journal of Computational Physics, 2014
A. Alikhanov
semanticscholar   +1 more source