Results 71 to 80 of about 793,794 (302)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Global Stability of a Rational Difference Equation

open access: yesDiscrete Dynamics in Nature and Society, 2010
We consider the higher-order nonlinear difference equation 𝑥𝑛+1=(𝑝+𝑞𝑥𝑛−𝑘)/(1+𝑥𝑛+𝑟𝑥𝑛−𝑘),𝑛=0,1,… with the parameters, and the initial conditions 𝑥−𝑘,…,𝑥0 are nonnegative real numbers.
Guo-Mei Tang, Lin-Xia Hu, Gang Ma
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Oscillatory properties for Emden–Fowler type difference equations with oscillating coefficients

open access: yesResults in Applied Mathematics
In this paper, we give new criteria on the oscillation of the fourth-order Emden–Fowler type delay difference equation with oscillating coefficients of the form ΔWn+rnyn−τβ=0,n≥n0,where Wn=pnΔ3vnα and vn=yn+qnyn−σ.
Yaşar Bolat   +2 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

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