Results 21 to 30 of about 121,153 (204)

Active and Passive Fields in Turbulent Transport: the Role of Statistically Preserved Structures

, 2002
We have recently proposed that the statistics of active fields (which affect the velocity field itself) in well-developed turbulence are also dominated by the Statistically Preserved Structures of auxiliary passive fields which are advected by the same ...
A. Brandenburg, A. Celani, A. Celani, E.S. C Ching, Emily S. C. Ching, G. Falkovich, I. Arad, Itamar Procaccia, P. Giuliani, Thomas Gilbert, V.S. L’vov, Y. Cohen, Yoram Cohen   +12 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Dimensional Crossovers in the Doped Ladder System: Spin Gap, Superconductivity and Interladder Coherent Band Motion

, 1998
Based on the perturbative renormalization group (PRG) approach, we have studied dimensional crossovers in Hubbard ladders coupled via weak interladder one-particle hopping, $t_{\perp}$.
Akimitsu J., Anderson P. W., Arai M., Balents L., Boies D., Bourbonnais C., Bourbonnais C., Bourbonnais C., Brazovskii S. A., Castellani C., Clarke D. G., Eccleston R. S., Fabrizio M., Finkel'stein A. M., Firsov Yu. A., Frahm H., Hayward C. A., Kawakami N., Khveshchenko D. V., Khveshchenko D. V., Kishine J., Kondo J., Kumagai K., Kuroki K., Lin H-H., Magishi K., Mizuno Y., Motoyama N., Nagaosa N., Nagaosa N., Nersesyan A. A., Noack R. M., Osafune T., Poilblanc D., Sano K., Schulz H. J., Schulz H. J., Shelton D. G., Suhl H., Suzumura Y., Sólyom J., Takigawa M., Troyer M., Tsuji S., Tsunetsugu H., Tsunetsugu H., Uehara M., Voit J., Yakovenko V. M., Yamaji K., Yoshioka H.   +50 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Nonequilibrium Critical Phenomena

, 2000
We discuss the non-equilibrium critical phenomena in liquids, and the models for these phenomena based on local equilibrium and extended scaling assumptions. Special situations are proposed for experimental tests of the theory.
Alexander Patashinski, Falkovich, Grinstein, Hohenberg, Kadanoff, Kawasaki, Kirkpatrick, Landau, Li, Li, Onuki, Onuki, Patashinski, Patashinski, Patashinski, Patashinski, Patashinskii, Schmitz, Schmitz, Sengers, Wilson   +20 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Scaling Exponents in Anisotropic Hydrodynamic Turbulence

, 2002
In anisotropic turbulence the correlation functions are decomposed in the irreducible representations of the SO(3) symmetry group (with different "angular momenta" $\ell$).
A. Pumir, A. Pumir, I. Arad, I. Arad, I. Arad, I. Arad, I. Arad, I. Arad, Itamar Procaccia, J.L. Lumley, L. Biferale, L. Biferale, R.H. Kraichnan, S. Garg, S. Grossmann, S. Kurien, S. Kurien, Vasil Tiberkevich, Victor S. L’vov, X. Shen   +19 more
core   +1 more source