Results 51 to 60 of about 9,754,609 (205)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni   +19 more
wiley   +1 more source

Existence of Solutions to a System of Fractional q-Difference Boundary Value Problems

open access: yes
We are investigating the existence of solutions to a system of two fractional q-difference equations containing fractional q-integral terms, subject to multi-point boundary conditions that encompass q-derivatives and fractional q-derivatives of different
Rodica Luca, Alexandru Tudorache
core   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin   +11 more
wiley   +1 more source

On the Nonlocal Fractional Delta-Nabla Sum Boundary Value Problem for Sequential Fractional Delta-Nabla Sum-Difference Equations

open access: yes, 2020
In this paper, we propose sequential fractional delta-nabla sum-difference equations with nonlocal fractional delta-nabla sum boundary conditions.
Jiraporn Reunsumrit   +1 more
core   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou   +16 more
wiley   +1 more source

On Sequential Fractional q-Hahn Integrodifference Equations

open access: yes, 2020
In this paper, we prove existence and uniqueness results for a fractional sequential fractional q-Hahn integrodifference equation with nonlocal mixed fractional q and fractional Hahn integral boundary condition, which is a new idea that studies q and ...
Nichaphat Patanarapeelert   +2 more
core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Backward difference replacements of the space derivative in first order hyperbolic equations [PDF]

open access: yes, 1983
Two families of two-time level difference schemes are developed for the numerical solution of first order hyperbolic partial differential equations with one space variable.
Khaliq, AQM, Twizell, EH
core   +3 more sources

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Periodic q-difference equations [PDF]

open access: yes, 2012
The concept of periodic functions defined on the real numbers or on the integers is a classical topic and has been studied intensively, yielding numerous applications in every kind of science.
Chieochan, Rotchana
core   +1 more source

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