Results 121 to 130 of about 506,766 (243)

Frequency-Invariant Representation of Interaural Time Differences in Mammals [PDF]

, 2011
Interaural time differences (ITDs) are the major cue for localizing low-frequency sounds. The activity of neuronal populations in the brainstem encodes ITDs with an exquisite temporal acuity of about .
Hannes Lüling, Benedikt Grothe, Siveke Ida, Siveke, Ida, Grothe, Benedikt, Christian Leibold, Grothe Benedikt, Leibold Christian, Lüling, Hannes, Leibold, Christian, Ida Siveke, Lüling Hannes   +11 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Democratization drives the adoption of national agri-environmental policies

Environmental Research Letters
Is democratic governance a key driver of environmental policy in the agricultural sector? We address this question using a global dataset covering national-level agri-environmental policies and regime transitions between autocracy and democracy from 1961
Paolo Nota, Daniele Curzi, Alessandro Olper   +2 more
doaj   +1 more source

Fuzzy differences in differences [PDF]

, 2010
Difference in differences require that 0% of observations are treated in the control group and during period 0 (no "always takers") and 100% in the treatment group in period 1 (no "never takers"). Sometimes, the treatment rate increases more in the treatment than in the control group but there are never or always takers.
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A micro level empirical analysis of Chinese steel exporter responses to the expected carbon border adjustment mechanism

Discover Sustainability
Against the backdrop of the imminent implementation of the EU Carbon Border Adjustment Mechanism (CBAM), China’s steel exports face significant external carbon cost shocks. As a core sector of heavy industry with high carbon emissions, the steel industry
Chenbo Xing
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The substitution of worksharing and short-time compensation in France: a difference-in-differences approach [PDF]

, 2009
he short-time compensation (STC) program aims at avoiding redundancies in case of strong short-term downturns. In the literature, STC is an instrument of both job security and flexibility.
Duhautois, R., Walkowiak, E., Calavrezo, O.   +2 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Spatiotemporal Evolution and Influence Mechanism of Talent Agglomeration and Knowledge Spillover under the Integration of the Yangtze River Delta

Redai dili
The primary objective of a regional integration strategy is to foster talent agglomeration and knowledge spillover, thereby enhancing the high-quality development of the regional economy.
Jin Cai, Li Tan, Hui Baohang, Lao Xin, Shen Tiyan   +4 more
doaj   +1 more source