Results 91 to 100 of about 1,304,903 (278)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A numerical study of spatio-temporal COVID-19 vaccine model via finite-difference operator-splitting and meshless techniques. [PDF]
Sci Rep, 2023 Khan AA +6 more
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The effect of the Caputo fractional difference operator on a new discrete COVID-19 model. [PDF]
Results Phys, 2022 Abbes A +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Orlicz Generalized Difference Sequence Space and the Linked Pre-Quasi Operator Ideal
Journal of Mathematics, 2020 In this article, the necessary conditions on s-type Orlicz generalized difference sequence space to generate an operator ideal have been examined. Therefore, the s-type Orlicz generalized difference sequence space which fails to generate an operator ...
Awad A. Bakery, OM Kalthum S. K. Mohamed
doaj +1 more source
Differences of weighted composition operators
Collectanea mathematica, 2009 Let \(\mathbb D\) be the open unit disk in the complex plane \(\mathbb C\), \(\varphi:{\mathbb D}\rightarrow {\mathbb D}\), \(\psi:{\mathbb D}\rightarrow {\mathbb C}\) be analytic functions. The weighted composition operator is acting on the functions defined on \(\mathbb D\) by the formula \[ (C_{\varphi,\psi}f)(z)=\psi(z)f(\varphi(z)), \quad z\in ...
openaire +3 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
An Operator-Difference Method for Telegraph Equations Arising in Transmission Lines
Discrete Dynamics in Nature and Society, 2011 A second-order linear hyperbolic equation with time-derivative term subject to appropriate initial and Dirichlet boundary conditions is considered. Second-order unconditionally absolutely stable difference scheme in (Ashyralyev et al.
Mehmet Emir Koksal
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source