Results 91 to 100 of about 110,219 (262)
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Fuzzy Difference Operators for Spatial Change Detection in 2D Spatial Scene
Fuzzy difference operators are used in different fields of decision making processes, image analysis and computer vision applications. Change detection in a spatial scene is the basic issue in modeling relative motion between object pair. Many approaches
Nadeem Salamat, El-hadi Zahzah
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Differences of Operators of Lupaş Type
In the present article, we study the approximation of difference of operators and find the quantitative estimates for the difference of Lupaş operators with Lupaş-Szász operators and Lupaş-Kantorovich operators in terms of modulus of continuity. Also, we find the quantitative estimate for the difference of Lupaş-Kantorovich operators and Lupaş-Szász ...
openaire +3 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
We discuss the lift of Poisson structures associated with auxiliary linear problems for the differential and difference Lax equations to the space of wave functions.
Semenov-Tian-Shansky Michael
doaj +1 more source
On the Correctness of Polynomial Difference Operators
Summary: The correctness Cauchy problem is explored for a polynomial difference operator. The easily verifiable sufficient condition correctness for the Cauchy problem for a polynomial difference operator with constant coefficients is proved whose characteristic polynomial is homogeneous.
openaire +3 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Arbitrary Order Fractional Difference Operators with Discrete Exponential Kernels and Applications
Recently, Abdeljawad and Baleanu have formulated and studied the discrete versions of the fractional operators of order ...
Thabet Abdeljawad +2 more
doaj +1 more source

