Results 121 to 130 of about 16,265,295 (241)

On cyclic reduction and finite difference schemes

open access: yes, 2002
We investigate a family of finite difference schemes for discretizing the two dimensional Poisson equation on both the standard and the reduced grids. We study the relation between the cyclic reduction method and the discretization schemes on different ...
Othman, Mohamed   +2 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Bayes finite difference schemes

open access: yes, 1993
Solomonoff, Alex. (1993). Bayes finite difference schemes.
Solomonoff, Alex
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Символьное исследование и численные эксперименты на разностной схеме для волновых процессов в соосных цилиндрических оболочках, заполненных несжимаемой вязкой жидкостью

open access: yesVestnik KRAUNC: Fiziko-Matematičeskie Nauki
Исследуются волновые процессы в системе двух соосных бесконечно длинных цилиндрических упругих оболочек, пространство между которыми заполнено вязкой несжимаемой жидкостью.
Месянжин, А.В.
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

ON SOME PROBLEMS OF THERMAL CONDUCTIVITY OF UNIDIRECTIONALLY REINFORCED MATERIALS

open access: yesВестник Кемеровского государственного университета, 2014
Structural model of thermal conductivity of unidirectionally reinforced layer is under consideration. The assumption that temperatures are equal within represented element of reinforced layer is addressed in the present research.
A. V. Stanislavovich
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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