Results 191 to 200 of about 16,265,295 (241)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

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Some high-order difference schemes for the distributed-order differential equations

Journal of Computational Physics, 2015
Hai-Wei Sun, Zhi-Zhong Sun, Guang-Hua Gao   +2 more
exaly   +2 more sources

Spectral analysis of finite difference schemes for convection diffusion equation

Computers and Fluids, 2017
Tapan Sengupta
exaly   +2 more sources

Some temporal second order difference schemes for fractional wave equations

Numerical Methods for Partial Differential Equations, 2016
Hong Sun, Zhi-Zhong Sun, Guang-Hua Gao
exaly   +2 more sources

Robustness of fractional difference schemes via the Caputo subdiffusion-reaction equations

Chaos, Solitons & Fractals, 2018
In this paper, we develop a range of efficient and fast fractional difference schemes for the approximation of Caputo time-fractional subdiffusion-reaction equations.
K. Owolabi, A. Atangana
semanticscholar   +1 more source

Pollution-Free Finite Difference Schemes for Non-Homogeneous Helmholtz Equation

International Journal of Numerical Analysis and Modeling, 2014
In this paper, we develop pollution-free finite difference schemes for solving the non-homogeneous Helmholtz equation in one dimension. A family of high-order algorithms is derived by applying the Taylor expansion and imposing the conditions that the ...
Kun Wang, Y. Wong
semanticscholar   +1 more source

Additive Operator-Difference Schemes: Splitting Schemes

, 2013
Applied mathematical modeling isconcerned with solving unsteady problems. This bookshows how toconstruct additive difference schemes to solve approximately unsteady multi-dimensional problems for PDEs.
P. Vabishchevich
semanticscholar   +2 more sources