Results 241 to 250 of about 3,972,950 (311)

Education Towards Differences: Preventing Gender and Sex Discriminations in Subjects in the Age of Development

, 2017
Mariano Gianola, Giuseppe Masullo
openalex   +2 more sources

Integrating Dense Genotyping with High‐Throughput Phenotyping Empowers the Genetic Dissection of Berry Quality and Resilience Traits in Grapevine

Advanced Science, EarlyView.
Researchers develop advanced tools to study grapevine traits like berry quality and stress resilience. A 200K SNP array and high‐throughput phenotyping enable the identification of loci linked to berry shape, sugar content, acidity, and cold tolerance. Functional validation of genes such as NAC08 reveals roles in cold tolerance.
Yuyu Zhang, Yongjian Wang, Michael Henke, Pablo Carbonell‐Bejerano, Zemin Wang, Pierre‐François Bert, Yi Wang, Huayang Li, Junhua Kong, Peige Fan, Zhanwu Dai, Zhenchang Liang   +11 more
wiley   +1 more source

Supplementary Material for: Global Application of the Assessment of Communication Skills of Paediatric Endocrinology Fellows in the Management of Differences in Sex Development Using the ESPE E-Learning.Org Portal

, 2017
Kranenburg L.J.C., Reerds S.T.H., Martine Cools, J. Alderson, Miriam Muscarella, E. Magrite, M. J. Kuiper, S. Abdelgaffar, Antonio Balsamo, Raja Brauner, Jean‐Pierre Chanoine, Asma Deeb, Patricia Y. Fechner, Alexander J. German, Paul‐Martin Holterhus, Anders Juul, Berenice B. Mendonça, Karen Neville, Ana Nordenstrom, Wilma Oostdijk, Rodolfo A. Rey, M.M. Rutter, Neel Shah, X. Luo, Kalinka Grijpink, Drop S.L.S.   +25 more
openalex   +2 more sources

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

Advanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu, Xin Dong, Hao Zhou, Ze‐Yan Li, Bo Wang, Ya‐Ping Song, Zhi‐Bing Liu, Xue Lu, Yi‐Hao Zhang, Yichao Huang, Hua Wang, De‐Xiang Xu   +11 more
wiley   +1 more source

KDM6A Deficiency Induces Myeloid Bias and Promotes CMML‐Like Disease Through JAK/STAT3 Activation by Repressing SOCS3

Advanced Science, EarlyView.
Lysine demethylase 6A (KDM6A), an epigenetic regulator expressed in hematopoietic stem and progenitor cells (HSPCs), plays a critical role in hematopoietic homeostasis. Deficiency of KDM6A induces myeloid lineage skewing and drives the development of a chronic myelomonocytic leukemia (CMML)‐like disease.
Huiqiao Chen, Shufen Wang, Ruoyu Dong, Pinghui Yu, Tianyu Li, Liangning Hu, Mowang Wang, Zijun Qian, Hongyu Zhou, Xiaoyan Yue, Limengmeng Wang, Haowen Xiao   +11 more
wiley   +1 more source

De Novo Reconstruction of 3D Human Facial Images from DNA Sequence

Advanced Science, EarlyView.
This study introduces Difface, a novel deep‐learning model for reconstructing 3D facial images only from DNA data. By integrating transformer networks, spiral convolutions, and a diffusion model, Difface directly aligns high‐dimensional SNP data with 3D facial structures.
Mingqi Jiao, Jiarui Li, Bingxu Zhong, Siyuan Du, Shuning Li, Manfei Zhang, Qibin Zhang, Zhongming Liang, Fan Liu, Chunman Zuo, Sijia Wang, Luonan Chen   +11 more
wiley   +1 more source

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

Advanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han, Rui Hong, Cong Cao, Wanhua Feng, Wei Zhuang, Gui Wang, Jingchao Tang, Ya Yang, Chu Zhang, Aihua Zhou, Xuebin Qu   +10 more
wiley   +1 more source

The risk of mental disorders in patients with disorders/differences of sex differentiation/development (DSD) and Y chromosome

, 2020
Katarzyna Bajszczak, Maria Szarras‐Czapnik, Renata Walczak-Jędrzejowska, Katarzyna Marchlewska, Jolanta Słowikowska‐Hilczer   +4 more
openalex   +2 more sources

Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen

Advanced Science, EarlyView.
This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang, Mingyue Fan, Su Chin Heo, Sheila M. Adams, Thomas Li, Yuchen Liu, Qing Li, Claudia Loebel, Jason A. Burdick, X. Lucas Lu, David E. Birk, Farid Alisafaei, Robert L. Mauck, Lin Han   +13 more
wiley   +1 more source