Results 261 to 270 of about 3,972,950 (311)

Annexin A3 Represses Endothelial Permeability and Inflammation During Sepsis via Actin Cytoskeleton Modulation

Advanced Science, EarlyView.
Annexin A3 (ANXA3) plays an endogenous protective role in endothelial dysfunction in sepsis by stabilizing the actin cytoskeleton, modulating cell permeability, and inhibiting pATF2/CD62E inflammatory signaling. Abstract Increased endothelial permeability and a dysregulated inflammatory response play key roles in organ damage in sepsis.
Manyu Xing, Shuang Liang, Wei Cao, Qulian Guo, Wangyuan Zou   +4 more
wiley   +1 more source

Single‐Cell Sequencing‐Guided Annotation of Rare Tumor Cells for Deep Learning‐Based Cytopathologic Diagnosis of Early Lung Cancer

Advanced Science, EarlyView.
This study presents an innovative method to generate high‐quality, objectively annotated cytology datasets without relying on expert involvement. Large‐scale single‐cell DNA sequencing is used as an objective ground truth of cell annotation for generating an accurate, unbiased dataset of exfoliated tumor cells from bronchoalveolar lavage cytology ...
Yichun Zhao, Ruoran Qiu, Zhuo Wang, Yunyun Li, Xu Yang, Yanlin Li, Xiaohan Shen, Yun Liu, Ziqiang Chen, Qihan You, Qihui Shi   +10 more
wiley   +1 more source

Chromosome‐Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology

Advanced Science, EarlyView.
The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi, Pan Duan, Mengmeng Zhu, Rong Zhang, Zihua Zhao, Xin Nie, Hanhou He, Li Hou, Xianhui Wang   +8 more
wiley   +1 more source

Autonomous Self‐Evolving Research on Biomedical Data: The DREAM Paradigm

Advanced Science, EarlyView.
DREAM is a fully autonomous, self‐evolving biomedical research system capable of independently formulating scientific questions, performing analyses, and making new discoveries without human intervention. Validated in biomedical studies, DREAM significantly outperforms human scientists in research efficiency, accelerating scientific discovery and ...
Luojia Deng, Yijie Wu, Yongyong Ren, Hui Lu   +3 more
wiley   +1 more source

Dual‐Energy CT‐Based Assessment of Thrombotic Heterogeneity for Predicting Stroke Source and Response to Machine Thrombectomy: A Step Toward Visualization Thrombus Treatment

Advanced Science, EarlyView.
The research indicates that dual energy CT scanning can accurately predict the stroke source and clinical outcomes by analyzing thrombus heterogeneity. Based on histopathological analysis of thrombus components, these scans are better able to display thrombus details than standard CT scans, which is helpful for the development of visual navigation ...
Jingxuan Jiang, Sijia Wang, Fan Xiao, Hongmei Gu, Mingkang Wang, Hao Tian, Baohui Guan, Kai Sheng, Yijia Xiong, Huilin Zhao, Minda Li, Li Xu, Zheng Sun, Haiyan Du, Wenxian Du, Yuehua Li   +15 more
wiley   +1 more source

METTL14‐Induced M6A Methylation Increases G6pc Biosynthesis, Hepatic Glucose Production and Metabolic Disorders in Obesity

Advanced Science, EarlyView.
It is shown that obesity is associated with increases in hepatic METTL14 and m6A methylation of G6pc transcript. YTHDF1 and YTHDF3 bind to m6A‐marked G6pc mRNA to increase its synthesis. Hepatocyte‐specific deletion of Mettl14 decreases G6pc m6A methylation, G6pc biosynthesis, and G6pc‐mediated gluconeogenesis, alleviating glucose metabolic defects in ...
Qiantao Zheng, Xiao Zhong, Qianqian Kang, Zhiguo Zhang, Decheng Ren, Yong Liu, Liangyou Rui   +6 more
wiley   +1 more source

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Pia Mater‐Penetrable Lipopolymer Nanoparticles for Gliocyte‐Targeted IL‐10 mRNA Therapy Alleviate Paclitaxel‐Induced Peripheral Neuropathy

Advanced Science, EarlyView.
The P6CIT lipopolymer demonstrates superior transfection efficacy in the spinal cord and DRG, as well as enhanced penetration of the pia mater compared to the MC3 ionizable lipid. Intrathecal delivery of P6CIT LPNPs enables effective transfection in the gliocytes in the spinal cord and DRG.
Xinrou Lin, Lingyu Wei, Xiangpen Li, Ling Zeng, Yingsen Tang, Hongjin Wang, Hengjian Lu, Chenguang Li, Hongxuan Wang, Jinjin Chen, Ying Peng   +10 more
wiley   +1 more source