Results 111 to 120 of about 4,488,154 (291)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Psychology Research and Behavior Management, 2019 Sigrid Wimmer,1 Helmut K Lackner,2 Ilona Papousek,3 Manuela Paechter1 1Educational Psychology Unit, Department of Psychology, University of Graz, Graz 8010, Austria; 2Otto Loewi Research Center, Division of Physiology, Medical University of Graz, Graz ...
Wimmer S +3 more
doaj
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Association between attention performance and the different dimensions of DSM-5 depression symptoms. [PDF]
Front Psychiatry, 2023 Taboada Gjorup AL +7 more
europepmc +1 more source
Revisiting the economy by taking into account the different dimensions of well-being [PDF]
In standard economic models benevolent governments are the unique actors in charge to tackle the problem of reconciling individual with social wellbeing in presence of negative externalities and insufficient provision of public goods.
Becchetti, Leonardo
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Investigating different dimensions of sleep quality in medical university students [PDF]
طب کارIntroduction: Sleep is one of the most important circadian cycles and a complex biological pattern. Sleep and sleep disorders are crucial factors in the lives of individuals within society.
farahnaz kalantar mehrjardi +2 more
doaj
Understanding the different dimensions of healthcare systems: the 'interpreting voice' found in interpretation and translation services. [PDF]
BMJ Lead, 2023 Rana L.
europepmc +1 more source