Results 51 to 60 of about 4,843,262 (245)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Differentiable neural architecture search in equivalent space with exploration enhancement [PDF]

, 2023
Recent works on One-Shot Neural Architecture Search (NAS) mostly adopt a bilevel optimization scheme to alternatively optimize the supernet weights and architecture parameters after relaxing the discrete search space into a differentiable space. However,
Chang, X, Zhang, M, Li, H, Su, S, Pan, S, Ge, Z   +5 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Architecture-aware minimization (A2M): how to find flat minima in neural architecture search

Machine Learning: Science and Technology
Neural architecture search (NAS) has become an essential tool for designing effective and efficient neural networks. In this paper, we investigate the geometric properties of neural architecture spaces commonly used in differentiable NAS methods ...
Matteo Gambella, Fabrizio Pittorino, Manuel Roveri   +2 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

NAS-HR: Neural architecture search for heart rate estimation from face videos

Virtual Reality & Intelligent Hardware, 2021
Background: In anticipation of its great potential application to natural human-computer interaction and health monitoring, heart-rate (HR) estimation based on remote photoplethysmography has recently attracted increasing research attention.
Hao Lu, Hu Han
doaj   +1 more source

Partial Connection Based on Channel Attention for Differentiable Neural Architecture Search

, 2022
Differentiable neural architecture search (DARTS), as a gradient-guided search method, greatly reduces the cost of computation and speeds up the search. In DARTS, the architecture parameters are introduced to the candidate operations, but the parameters ...
Jiafeng Qin, Xue, Yu, Qin, Jiafeng, Yu Xue   +3 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Partially-Connected Differentiable Architecture Search for Deepfake and Spoofing Detection

, 2021
International audienceThis paper reports the first successful application of a differentiable architecture search (DARTS) approach to the deepfake and spoofing detection problems. An example of neural architecture search, DARTS operates upon a continuous,
Panariello, Michele, Wanying Ge, Jose Patino, Ge, Wanying, Evans, Nicholas, Michele Panariello, Nicholas Evans, Patino, Jose, Todisco, Massimiliano, Massimiliano Todisco   +9 more
core   +1 more source