Results 191 to 200 of about 887,542 (357)
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Ingeniare: Revista Chilena de Ingeniería, 2009 En este trabajo se presenta una aproximación para un número difuso de tipo trapezoidal por una secuencia de números difusos ε-diferenciables, es decir, números difusos cuya función de pertenencia es diferenciable en el interior del nivel ε.
Y Chalco-Cano +3 more
doaj
Algebras of some differentiable functions on Riemannian manifolds
, 1959 Mitsuru Nakai
openalex +2 more sources
Differentiability of Sample Functions in Gaussian Processes [PDF]
, 1967 J. Yeh
openalex +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
On the Differentiability Structure of Real Functions [PDF]
, 1969 A. M. Bruckner, J. G. Ceder, Max Weiss
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
On differentiability of reward functionals corresponding to Markovian randomized stopping times [PDF]
arXivWe conduct an investigation of the differentiability and continuity of reward functionals associated to Markovian randomized stopping times. Our focus is mostly on the differentiability, which is a crucial ingredient for a common approach to derive analytic expressions for the reward function.
arxiv
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Weighted Hermite-Hadamard-type inequalities without any symmetry condition on the weight function
Open MathematicsWe establish weighted Hermite-Hadamard-type inequalities for some classes of differentiable functions without assuming any symmetry property on the weight function.
Jleli Mohamed, Samet Bessem
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