Results 211 to 220 of about 28,027 (297)

Adjoint Algorithmic Differentiation: Calibration and Implicit Function Theorem

, 2011
Marc Henrard
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Nonlinear Stability in a Free Boundary Model of Active Locomotion. [PDF]

Arch Ration Mech Anal
Berlyand L, Safsten CA, Truskinovsky L.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Uncertainty weighted multi task learning for robust traffic scene semantic understanding. [PDF]

Sci Rep
Wan Z, Ye S, Wang F, Liu S, Peng L.
europepmc   +1 more source

Faculty Opinions recommendation of T cell receptor and cytokine signaling can function at different stages to establish and maintain transcriptional memory and enable T helper cell differentiation.

, 2019
Matthew E. Pipkin
openalex   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

HemaContour: explicit parametric contour learning for robust ICH segmentation on non-contrast CT. [PDF]

NPJ Digit Med
Zheng C, Xie G, Wang H, Ren B, Lin X, Jiang J, Jiang X, Zhang Z, Wang H, Zheng W.   +9 more
europepmc   +1 more source

A VARIANTE OF KATUGAMPOLA MILNE-TYPE INEQUALITIES FOR DIFFERENTIABLE s-CONVEX FUNCTIONS

Hicham Saber, Badreddine Meftah, Moheddine Imsatfia, Hamid Boulares, Abdelkader Moumen, Rafik Guefaifia, Ibrahim Mekawy   +6 more
openalex   +1 more source

Conserved domains and structural motifs that differentiate closely related Rex1 and Rex3 DEDDh Exoribonuclease families are required for their function in yeast [PDF]

Peter Daniels, Sophie Kelly, Iwan J. Tebbs, Philip Mitchell   +3 more
openalex   +1 more source