Results 191 to 200 of about 2,011 (255)

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

Mirror Descent and Exponentiated Gradient Algorithms Using Trace-Form Entropies. [PDF]

Entropy (Basel)
Cichocki A, Tanaka T, Nielsen F, Cruces S.   +3 more
europepmc   +1 more source

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

iAODE for benchmarking and continuum modeling of single-cell chromatin accessibility. [PDF]

Commun Biol
Fu Z, Chen C, Wang S, Wang J, Chen S.
europepmc   +1 more source

Computer-assisted construction of <i>SU</i>(2)-invariant negative Einstein metrics. [PDF]

Ann Glob Anal Geom (Dordr)
Wang QS.
europepmc   +1 more source

AI-Resolved Protein Energy Landscapes, Electrodynamics, and Fluidic Microcircuits as a Unified Framework for Predicting Neurodegeneration. [PDF]

Int J Mol Sci
Pantu C, Breazu A, Oprea S, Serban M, Covache-Busuioc RA, Munteanu O, Dobrin N, Costea D, Eva L.   +8 more
europepmc   +1 more source

Pólya-Szegő Inequalities on Submanifolds with Small Total Mean Curvature. [PDF]

J Geom Anal
Aldrigo P, Balogh ZM.
europepmc   +1 more source

Bang-bang control optimization in infectious disease model with incorporating breakthrough and reinfection. [PDF]

Sci Rep
Chen Y, Jing W, Zhang J, Qin P.
europepmc   +1 more source

AI-discovered tuning laws explain neuronal population code geometry

Tilbury R, Kwon D, Haydaroğlu A, Ratliff J, Schmutz V, Carandini M, Miller K, Stachenfeld K, Harris KD.   +8 more
europepmc   +1 more source