Results 91 to 100 of about 2,372,273 (212)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Probabilities of a lower-limit barrier in the problem of the identification of a barrier in the functioning of a certain inventory storage and issue system [PDF]
The paper investigates a barrier in the functioning of certain inventory system. Assuming that the storage input is a non-aggregated dynamic-parameter process, the paper derives a system of differential equations satisfied by the probabilities of a lower-
Jerzy Swiatek, Tadeusz Galanc
core
An Investigation of Differential Item Functioning and Differential Test Functioning Of Swusat during 2010-2013 [PDF]
, 2017 The purpose of this research was to analyze the differential item functioning (DIF) and the differential test functioning (DTF) of scholastic aptitude test (SWUSAT) for groups of students and classified by gender.
Choptham, Manida +4 more
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Psychometrics: From practice to theory and back
nonparametric IRT, NIRT, latent unidimensionality, latent multidimensionality, essential unidimensionality, monotone locally independent unidimensional IRT model, MLI1, item pair conditional covariances, DIMTEST, HCA/CCPROX, DETECT, CONCOV, Mokken ...
William Stout
core +1 more source
Numerical solution and structural analysis of differential-algebraic equations [PDF]
, 2002 In the last two decades differential-algebraic equations (DAEs) have become an important branch in numerical analysis. In this Thesis we study them from a new, geometric point of view.
Arponen, Teijo
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source