Results 101 to 110 of about 621 (212)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

APPLICATION OF INFORMATION FUNCTIONS FOR THE ANALYSIS AND EFFECTIVENESS INCREASE OF THE TESTS IN HIGHER MATHEMATICS

Інформаційні технології і засоби навчання, 2014
The present paper studies the issue of effectiveness analysis of pedagogical tests based on calculation of information functions. The algorithms of computation and analysis of information function depending on the type of test item and the chosen model ...
Oleksandr A. Dykhovychnyi, Anna F. Dudko
doaj  

Provable Security against EDP-based Differential Cryptanalysis for Two-Round Arithmetization-Oriented SPNs with MDS Mixing

IACR Transactions on Symmetric Cryptology
Arithmetization-oriented (AO) primitives play an important role in making modern zero-knowledge proof (ZKP) and multiparty computation (MPC) systems efficient enough for practical use.
Alex Biryukov, Duy Nguyen
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Fractional Powers of Anti-Triangular Operator Matrices and Their Applications

Axioms
The concept of fractional powers of operators was initially developed within the framework of functional analysis and has since played a significant role in the study of evolution equations, abstract differential equations, and complex dynamical systems.
Lei Zhao, Yongqing Fu, Junjie Huang
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Dynamics of quasi-periodic, bifurcation, sensitivity and three-wave solutions for (n + 1)-dimensional generalized Kadomtsev-Petviashvili equation.

PLoS ONE
This study endeavors to examine the dynamics of the generalized Kadomtsev-Petviashvili (gKP) equation in (n + 1) dimensions. Based on the comprehensive three-wave methodology and the Hirota's bilinear technique, the gKP equation is meticulously examined.
Muhammad Hamza Rafiq, Muhammad Bilal Riaz, Ghada Ali Basendwah, Nauman Raza, Muhammad Naveed Rafiq   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source