Results 161 to 170 of about 621 (212)

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Baseline of Differential Thermal Analysis Compensated and Corrected by Computer

水土保持学报, 2000
openaire   +1 more source

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Exploiting Linearity in White-Box AES With Differential Computation Analysis

Advances in Intelligent Systems and Computing, 2020
Not only have all current scientific white-box AES schemes been mathematically broken, they also face a family of attacks derived from traditional Side Channel Attacks, e.g., Differential Computation Analysis (DCA) introduced by Bos et al. Such attacks are very universal and easy-to-mount – they require neither knowledge of the implementation, nor use ...
Martin Novotny
exaly   +3 more sources

Synthesis and Analysis of Elementary Algorithms for a Differential Neural Computer

Lobachevskii Journal of Mathematics, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Rakhmatullin, A. Kh., Gibadullin, R. F.
openaire   +1 more source

Computational Analysis and Studies on Differential Ejector

Applied Mechanics and Materials, 2011
Studies on differential ejector configuration have been carried out with a view to obtain the optimal entrainment of low pressure gas flow by injecting the motive gas at an appropriate pressure and angle of injection. The length of mixing has been kept constant in one case and varied in another to get results for optimal angle of ejection (between 0 to
Ankit Tyagi, Bhisham Gudwani, Gaurav Singhal   +2 more
openaire   +1 more source

Theoretical analysis of evolutionary computation on continuously differentiable functions

Proceedings of the 12th annual conference on Genetic and evolutionary computation, 2010
This paper investigates theoretically the convergence properties of the stochastic algorithms of a class including both CMAESs and EDAs on constrained minimization of continuously differentiable functions. We are interested in algorithms that do not get stuck on a slope of the function, but converge only to local optimal points.
Youhei Akimoto, Yuichi Nagata, Isao Ono, Shigenobu Kobayashi   +3 more
openaire   +2 more sources