Results 31 to 40 of about 621 (212)

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

A Hyper-Dual Number Approach to Higher-Order Derivative Computation

Axioms
This paper develops a theoretical framework for the computation of higher-order derivatives based on the algebra of hyper-dual numbers. Extending the classical dual number system, hyper-dual numbers provide a natural and rigorous mechanism for encoding ...
Ji Eun Kim
doaj   +1 more source

Evolutionary Computation Methods and their applications in Statistics

Statistica, 2013
A brief discussion of the genesis of evolutionary computation methods, their relationship to artificial intelligence, and the contribution of genetics and Darwin’s theory of natural evolution is provided.
Francesco Battaglia
doaj   +1 more source

Spinning correlators in N $$ \mathcal{N} $$ = 2 SCFTs: Superspace and AdS amplitudes

Journal of High Energy Physics, 2023
We study four-point functions of spinning operators in the flavor current multiplet in four dimensional N $$ \mathcal{N} $$ = 2 SCFTs, using superspace techniques.
Agnese Bissi, Giulia Fardelli, Andrea Manenti, Xinan Zhou   +3 more
doaj   +1 more source

Stability Analysis in Milling Based on the Localized Differential Quadrature Method

Micromachines, 2023
Chatter stability analysis is an effective way to optimize the cutting parameters and achieve chatter-free machining. This paper proposes a milling chatter stability analysis method based on the localized differential quadrature method (LDQM), which has ...
Yonggang Mei, Bingbing He, Shangwen He, Xin Ren   +3 more
doaj   +1 more source

tappAS: a comprehensive computational framework for the analysis of the functional impact of differential splicing [PDF]

Genome Biology, 2020
Abstract Recent advances in long-read sequencing solve inaccuracies in alternative transcript identification of full-length transcripts in short-read RNA-Seq data, which encourages the development of methods for isoform-centered functional analysis.
Lorena de la Fuente, Ángeles Arzalluz-Luque, Manuel Tardáguila, Héctor del Risco, Cristina Martí, Sonia Tarazona, Pedro Salguero, Raymond Scott, Alberto Lerma, Ana Alastrue-Agudo, Pablo Bonilla, Jeremy R. B. Newman, Shunichi Kosugi, Lauren M. McIntyre, Victoria Moreno-Manzano, Ana Conesa   +15 more
openaire   +4 more sources

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

The First- and Second-Order Features Adjoint Sensitivity Analysis Methodologies for Neural Integro-Differential Equations of Volterra Type: Mathematical Framework and Illustrative Application to a Nonlinear Heat Conduction Model

Journal of Nuclear Engineering
This work presents the mathematical frameworks of the “First-Order Features Adjoint Sensitivity Analysis Methodology for Neural Integro-Differential Equations of Volterra-Type” (1st-FASAM-NIDE-V) and the “Second-Order Features Adjoint Sensitivity ...
Dan Gabriel Cacuci
doaj   +1 more source

Coevolution of Artificial Agents Using Evolutionary Computation in Bargaining Game

Advances in Multimedia, 2015
Analysis of bargaining game using evolutionary computation is essential issue in the field of game theory. This paper investigates the interaction and coevolutionary process among heterogeneous artificial agents using evolutionary computation (EC) in the
Sangwook Lee
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source