Results 161 to 170 of about 6,359,259 (380)

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

Overactive bladder, differential diagnosis, and clinical utility of fesoterodine

open access: yesInternational Journal of General Medicine, 2012
Jean-Jacques WyndaeleDepartment of Urology, Antwerp University, Antwerp, BelgiumAbstract: Overactive bladder is a symptom syndrome with urgency, frequency and, in many cases, nocturia. Urge incontinence is not present in all.
Wyndaele J-J
doaj  

MEDDxAgent: A Unified Modular Agent Framework for Explainable Automatic Differential Diagnosis [PDF]

open access: yesarXiv
Differential Diagnosis (DDx) is a fundamental yet complex aspect of clinical decision-making, in which physicians iteratively refine a ranked list of possible diseases based on symptoms, antecedents, and medical knowledge. While recent advances in large language models have shown promise in supporting DDx, existing approaches face key limitations ...
arxiv  

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

open access: yesMolecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan   +6 more
wiley   +1 more source

Lymphangioleiomyomatosis: differential diagnosis and optimal management

open access: yesTherapeutics and Clinical Risk Management, 2014
Kai-Feng Xu,1 Bee Hong Lo2 1Department of Respiratory Medicine, Peking Union Medical College Hospital, Beijing, People's Republic of China; 2Developmental Pediatrician, PECAT, Children's Hospital Westmead, Sydney, NSW, Australia Abstract ...
Xu KF, Lo BH
doaj  

ProAI: Proactive Multi-Agent Conversational AI with Structured Knowledge Base for Psychiatric Diagnosis [PDF]

open access: yesarXiv
Most LLM-driven conversational AI systems operate reactively, responding to user prompts without guiding the interaction. Most LLM-driven conversational AI systems operate reactively, responding to user prompts without guiding the interaction. However, many real-world applications-such as psychiatric diagnosis, consulting, and interviews-require AI to ...
arxiv  

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