Results 251 to 260 of about 6,359,259 (380)

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Differential diagnosis of pigmented nail lesions. [PDF]

An Bras Dermatol
Bertanha L, Noriega LF, Di Chiacchio NG, Matter A, Di Chiacchio N.   +4 more
europepmc   +1 more source

Differential Diagnosis in Psychiatry: A Comparison of Symptoms in Various Disease States [PDF]

, 1918
Lawson G. Lowkey
openalex   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Crowned dens syndrome: a rare differential diagnosis of meningitis. [PDF]

CJEM
Palmowski A, Riedel J, Kamieniarz P, Haibel H, Bartsch L, Diehl-Wiesenecker E.   +5 more
europepmc   +1 more source

The Symptomatology and Differential Diagnosis of Tuberculosis of the Cecum [PDF]

, 1910
Charles Greene Cumston
openalex   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Explainable graph neural network based on metabolic brain imaging for differential diagnosis of parkinsonism. [PDF]

Front Aging Neurosci
Ling R, Cen X, Wu S, Wang M, Zhang Y, Jiang J, Lu J, Liu Y, Zuo C, Jiang J, Yang Y, Yan Z.   +11 more
europepmc   +1 more source

Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding

FEBS Open Bio, EarlyView.
The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla, Faiza Abbas, Luigia Rossi, Mauro Magnani, Sara Biagiotti   +4 more
wiley   +1 more source

Differential diagnosis of diphtheria from membranous croup [PDF]

, 1899

openalex   +1 more source