Results 51 to 60 of about 4,228,827 (257)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Cryptographic secrecy of steganographic matrix encoding

Tongxin xuebao, 2012
Based on an information theory model,the cryptographic security of matrix encoding,which can be applied in steganographic codes or wet paper codes,under different attack conditions was studied.The cryptographic security about matrix encoding under the ...
Jia-yong CHEN, Jiu-fen LIU, Yue-fei ZHU, Wei-ming ZHANG   +3 more
doaj   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Nuclear protein of the testis midline carcinoma masquerading as a primary mediastinal seminoma

Rare Tumors, 2016
Nuclear protein of the testis (NUT) midline carcinomas are rare aggressive carcinomas characterized by chromosomal rearrangements that involve the gene encoding the NUT.
Maria S. Sayapina, Nikita A. Savelov, Apollon I. Karseladze, Anatoly A. Bulanov, Alexey A. Tryakin, Dmitry A. Nosov, Avgust M. Garin, Sergey A. Tjulandin   +7 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Differential-Clustering Compression Algorithm for Real-Time Aerospace Telemetry Data

IEEE Access, 2018
The volume of telemetry data is gradually increasing, both because of the increasingly larger number of parameters involved and the use of higher sampling frequencies.
Xuesen Shi, Yuyao Shen, Yongqing Wang, Li Bai   +3 more
doaj   +1 more source

The role of mPFC and MTL neurons in human choice under goal-conflict

Nature Communications, 2020
Optimizing approach-avoidance behavior calls for neural encoding of related motivation outcomes. Here, the authors show that behavioral choice under conflict relies on differential neuronal firing patterns after punishment, in which mPFC neurons decode ...
Tomer Gazit, Tal Gonen, Guy Gurevitch, Noa Cohen, Ido Strauss, Yoav Zeevi, Hagar Yamin, Firas Fahoum, Talma Hendler, Itzhak Fried   +9 more
doaj   +1 more source

Differential Encoding of Losses and Gains in the Human Striatum

Journal of Neuroscience, 2007
Studies on human monetary prediction and decision making emphasize the role of the striatum in encoding prediction errors for financial reward. However, less is known about how the brain encodes financial loss. Using Pavlovian conditioning of visual cues
B. Seymour, N. Daw, P. Dayan, T. Singer, R. Dolan   +4 more
semanticscholar   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source