Results 151 to 160 of about 21,246 (258)

Redox signaling modulates nitrite transport in a commensal Streptococcus. [PDF]

Redox Biol
Edmonds SE, Baty JJ, Scoffield JA.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Circulating Tumor Cells: Isolation, Preclinical Models, and Clinical Applications for Personalized Cancer Therapy. [PDF]

Biomolecules
Sisca L, Polito MG, Iuliani M, Papalia GF, Tonini G, Pantano F.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analytical Verification and Method Comparison of the Atellica HEMA 580 Hematology Analyzer for Routine Clinical Laboratory Implementation in a Tertiary Care Setting. [PDF]

Cureus
Al Zaabi M, Al Mawali A, Al Mamari S, Al Buraiki M, Deepak M.   +4 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Circulating Tumour Cells as Potential Biomarkers for Oral Squamous Cell Carcinoma. [PDF]

Molecules
Mabongo M, Chipiti T, Hull R, Sibiya L, Phakathi B, Dlamini Z.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Plasma extracellular vesicle proteomics nominates candidate biomarkers of ¹⁷⁷Lu-PSMA-617 outcomes in metastatic prostate cancer patients. [PDF]

Cell Rep Med
Arafa AT, Boytim E, Ludwig ML, Kollitz L, Yang T, Storey KM, Bloom S, Jha G, Okazaki I, Ryan CJ, Zorko NA, Steinberger D, Cayci Z, Zhao Y, Villalta PW, Dehm SM, Hwang JH, Drake JM, Antonarakis ES.   +18 more
europepmc   +1 more source

Evaluation on Selective and Differential Medium (AFPA) for Enumeration of Aspergillus flavus in Imported Foods

Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 1994
SUZUKI, Meiko, NARITA, Noriko, KIKUCHI, Yutaka, ICHINOE, Masakatsu   +3 more
openaire   +2 more sources