Results 151 to 160 of about 6,715,931 (355)
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The investigation of delay differential equations (DDEs) spans a diverse array of practical applications. In the realm of applied sciences, DDEs typically involve either constant/pure delays or proportional delays, each posing significant analytical ...
Essam R. El-Zahar +3 more
doaj +1 more source
A novel computational method for solving nonlinear Volterra integro-differential equation
Musa Çakır +2 more
openalex +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Differential equation refers to an equation that includes a function and its derivatives. These equations serve to model real-world situations where rates of change are significant.
Mohammad Sajid +3 more
doaj +1 more source
Existence results for some integro-differential equations with state-dependent nonlocal conditions in Fréchet Spaces [PDF]
Mamadou Abdoul Diop +3 more
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
A linear dynamic feedback controller for non-linear systems described by matrix differential equations of the second and first orders [PDF]
Paweł Skruch, Marek Długosz
openalex +1 more source

