Results 251 to 260 of about 395,881 (311)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

In reply: epidemiology of immune-mediated thrombotic thrombocytopenic purpura in Germany. [PDF]

Res Pract Thromb Haemost
Scharenberg AY, Voran JC, Thomsen SY, Pohlmeyer A, Walendy V, Völker LA, Schmitt R, von Samson-Himmelstjerna FA, Schulte K, Kolbrink B.   +9 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Distinguishing verrucous herpes from neoplastic lesions: A clinical and histopathological approach. [PDF]

JAAD Case Rep
Vattigunta M, Jaller JA.
europepmc   +1 more source

Site-Specific Phosphoproteomic Profiling of CAV1 Reveals Co-Regulatory Kinase Networks in Cancer Signaling. [PDF]

Int J Mol Sci
Vaz CE, Suresh M, Dcunha L, Raju R, Kanekar S.   +4 more
europepmc   +1 more source

Exploring Key Factors Affecting the Encapsulation Efficiency of Ligusticum Chuanxiong-Vinegar Cyperus Rotundus Essential Oil Based on QbD Principles. [PDF]

Pharmaceutics
Tang Z, Chen W, Zhang T, He Y, Wan H.
europepmc   +1 more source

Electrophysiological evidence of severe marginal mandibular branch injury in Bell palsy: Implications for optimizing clinical assessment and treatment - a retrospective study. [PDF]

Medicine (Baltimore)
Zhang Q, Xia M, Zhang J, Chen Y, Zou Z, Liu Y.   +5 more
europepmc   +1 more source