Results 231 to 240 of about 1,602,988 (296)

A Second Pathogenic Protein, PolyGN2C-iso2, Reveals a Dual-Protein Pathology in Neuronal Intranuclear Inclusion Disease. [PDF]

Adv Sci (Weinh)
Zhang K, Ma W, Zhou Y, Wu Z, Gao P, Niu H, Tai H, Zhao T, Dong Z, Li L, Zhang Y, Wang A, Shen S, Li Y, Yu S, Peng Y, Sheng W, Dong X, Pan H, Shi K, Koziol MJ, Wu X, Zhang Z.   +22 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Beyond motor neurons: peripheral TDP-43 pathology in skeletal muscle and intramuscular nerves in amyotrophic lateral sclerosis. [PDF]

Brain Commun
Corti S, Alberti C, Ottoboni L, Magni G, Gagliardi D, Marcotti F, Zanotti S, Moggio M, Comi GP.   +8 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Ultrastructural diversity and subcellular organization of nigral Lewy pathology in Parkinson's disease. [PDF]

Nat Commun
Lewis AJ, van den Heuvel L, Di Fabrizio M, Bandelier K, Proniakova D, Burger D, Shafiei N, Ekundayo K, Offringa S, Huisman E, Bol JG, van de Berg WD, Stahlberg H.   +12 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Oligodendroglial somatic SNCA copy number gains are associated with inclusions and disease onset in multiple system atrophy. [PDF]

Acta Neuropathol
Morley C, Kalef-Ezra E, Perez-Rodriguez D, Jaunmuktane Z, Proukakis C.   +4 more
europepmc   +1 more source

Mutation-specific neuropathologic signatures in MAPT-associated frontotemporal lobar degeneration. [PDF]

Acta Neuropathol
Bogdani M, Jadhav VS, Kraemer BC, Grabowski TJ, Jayadev S, Domoto-Reilly K, Liachko NF, Bird TD, Dirk Keene C, Latimer CS.   +9 more
europepmc   +1 more source

Coordinated topoisomerase function shapes the fluoroquinolone response of <i>Chlamydia trachomatis</i>. [PDF]

Microbiol Spectr
Terrebonne A, Diggs C, Ouellette SP, Gao L, Tse-Dinh Y-C, Shen L.   +5 more
europepmc   +1 more source