Results 121 to 130 of about 9,343 (207)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Alpha-synuclein misfolding as fluid biomarker for Parkinson's disease measured with the iRS platform. [PDF]

EMBO Mol Med
Schuler M, Gerwert G, Mann M, Woitzik N, Langenhoff L, Hubert D, Duman D, Höveler A, Galkowski S, Simon J, Denz R, Weber S, Kwon EH, Wanka R, Kötting C, Güldenhaupt J, Beyer L, Tönges L, Mollenhauer B, Gerwert K.   +19 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Cold-press sintering and particle-size engineering of Bi_0.3Sb_1.7Te₃ for enhanced thermoelectric performance. [PDF]

iScience
Xiong R, Lemoigne J, Rafferty A, Gascoin F, Pakdel A.   +4 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Gut microbial production of imidazole propionate drives Parkinson's pathologies. [PDF]

Nat Commun
Park H, Cheon J, Kim H, Kim J, Kim J, Shin JY, Kim H, Ryu G, Chung IY, Kim JH, Kim D, Zhang Z, Wu H, Beck KR, Bäckhed F, Kim HJ, Lee Y, Koh A.   +17 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Synthesis and Properties of Degradable Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate) [P(3HB-<i>co</i>-3HV)] Derived from Waste Fish Oil. [PDF]

Polymers (Basel)
Volova TG, Kiselev EG, Sukovatyi AG, Zhila NO, Sapozhnikova KY, Ipatova ND, Shishatskii PO.   +6 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Stomata biosilica and <i>Equisetum</i> photosynthesis: ionic tomography insight using a PDMPO silicaphilic probe. [PDF]

Chem Sci
Volkov VV, Hickman GJ, Perry CC.
europepmc   +1 more source