Results 161 to 170 of about 231,847 (348)

Validity of a visual impairment questionnaire in measuring cataract surgery outcomes [post print] [PDF]

open access: yes, 2008
PURPOSE: To test the validity of the Impact of Visual Impairment (IVI) questionnaire in a cataract population. SETTING: Flinders Eye Centre, Flinders Medical Centre, Flinders University, Adelaide, South Australia.
Caudle, Lynda Elisabeth   +3 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Un meta-análisis del procedimiento Mantel-Haenszel en la detección del DIF en ítems dicotómicos [PDF]

open access: yes, 2016
The study describes the present state of research into the effectiveness of the Mantel-Haenszel technique (MH) to detect Differential Item Function ing (DIF) in dichotomous items, and analyses the influence of diverse variables on the statistical power ...
Guilera Ferré, Georgina   +3 more
core  

Differential item functioning in multiple choice items

open access: yes, 1990
In multiple-choice items the response probability on an item may be viewed as the result of two distinct latent processes--a cognitive process to solve the problem, and another random process that leads to the choice of a certain alternative (the process of giving the actual response).
Westers, Paul, Kelderman, Henk
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Differential Item Functioning of the Jaw Functional Limitation Scale [PDF]

open access: yesJ Oral Facial Pain Headache, 2023
Pattanaik S, John MT, Chung S, Keller S.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

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