Results 201 to 210 of about 3,562,253 (279)

Microglial Ccl4-Ccr5 signaling links systemic inflammation to synaptic loss and memory deficits in chronic kidney disease. [PDF]

J Neuroinflammation
Cao Y, Wang J, Li X, Chen X, Xiong J, Wang T, Sun H, Wang Z.   +7 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Intramuscular Glomus Tumor of Foot Presenting as Neuroma of Sural Nerve: A Case Report. [PDF]

J Orthop Case Rep
Lingaiah P, Rajasekhar JV, Joseph MU, Chauhan A, Reddy SSK, Nataraj AR.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Time series data with and without anomalies from a continuous distillation plant. [PDF]

Sci Data
Muraleedharan A, Ferre A, Arweiler J, Jungjohann I, Jirasek F, Hasse H, Burger J.   +6 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

An emergent disease-associated motor neuron state precedes cell death in ALS. [PDF]

Cell
Gautier O, Blum JA, Nguyen TP, Cao S, Klemm S, Yamakawa M, Huh D, Hurt JA, Sinnott-Armstrong N, Zeng Y, Davis CO, Bombosch J, Liu C, Encarnacion LN, Guttenplan KA, Chen D, Kathiria A, Zhao L, Moore S, Meng A, Ong K, Cleveland DW, Ravits J, Rexach JE, Greenleaf WJ, Gitler AD.   +25 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

IsoformSwitchAnalyzeR v2: analysis of functional isoform changes in long-read and single-cell sequencing data. [PDF]

NAR Genom Bioinform
Han C, Gilis J, Delgado EI, Clement L, Vitting-Seerup K.   +4 more
europepmc   +1 more source