Results 81 to 90 of about 32,830 (265)
Characterization of domains of symmetric and self-adjoint ordinary differential operators
Electronic Journal of Differential Equations, 2018 We characterize the two point boundary conditions which determine symmetric ordinary differential operators of any order, even or odd, with complex coefficients and arbitrary deficiency index, in a Hilbert space.The self-adjoint characterizations ...
Aiping Wang, Anton Zettl
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2014 The contribution aims to create hypergroups of linear first-order partial differential operators with proximities, one of which creates a tolerance semigroup on the power set of the mentioned differential operators.
Chvalina Jan +1 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Operator Calculus of Differential Chains and Differential Forms [PDF]
The Journal of Geometric Analysis, 2013 68 pages, 14 figures. First posted on the arxiv in 2012, published in Springer's First online 05 September 2013 and published in The Journal of Geometric Analysis, January 2015. Since this paper was posted, two unrelated applications have been published: arXiv:1310.0508 and Seguin and Fried, Math. Models Methods Appl. Sci. 24, 1729 (2014).
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Differential Operators and Differential Calculus on $delta-$Hom-Jordan-Lie Superalgebras
پژوهشهای ریاضی, 2020 Introduction Hom-algebraic structures appeared first as a generalization of Lie algebras in [1,3], where the authors studied q-deformations of Witt and Virasoro algebras. A general study and construction of Hom-Lie algebras
Valiollah Khalili
doaj