Results 81 to 90 of about 1,878,592 (297)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Degenerate Differential Operators with Parameters
Abstract and Applied Analysis, 2007 The nonlocal boundary value problems for regular degenerate differential-operator equations with the parameter are studied. The principal parts of the appropriate generated differential operators are non-self-adjoint.
Veli B. Shakhmurov
doaj +1 more source
A novel HIV model through fractional enlarged integral and differential operators. [PDF]
Sci Rep, 2023 Barakat MA, Hyder AA, Almoneef AA.
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A Classification of Fourth-Order Dissipative Differential Operators
Journal of Function Spaces, 2020 This paper is devoted to the classification of the fourth-order dissipative differential operators by the boundary conditions. Subject to certain conditions, we determine some nonself-adjoint boundary conditions that generate the fourth-order ...
Tao Wang, Ji-jun Ao, Mei-chun Yang
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
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Boundedness of Gevrey and Gelfand-Shilov kernels of positive semi-definite operators
, 2015 We show that the strongest Gevrey irregularity of kernels to positive semi-definite operators appear at the diagonals. We also prove that positive elements with respect to the twisted convolution, belonging to a Gevrey class of certain order at the ...
Toft, Joachim,, Chen, Yuanyuan,
core +1 more source
Some further classes of pseudo-differential operators in the p-adic context and their applications. [PDF]
J Pseudodiffer Oper Appl, 2023 Torresblanca-Badillo A +1 more
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source