Results 121 to 130 of about 340,748 (309)
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Journal of Dairy Science, 2023 : Mastitis has detrimental effects on the world's dairy industry, reducing animal health, milk production and quality, as well as income for farmers. In addition, consumers' growing interest in food safety and rational usage of antibiotics highlights the
T. Bobbo +6 more
doaj
Stochastic nonlinear model for somatic cell population dynamics during ovarian follicle activation [PDF]
arXiv, 2019 In mammals, female germ cells are sheltered within somatic structures called ovarian follicles, which remain in a quiescent state until they get activated, all along reproductive life. We investigate the sequence of somatic cell events occurring just after follicle activation, starting by the awakening of precursor somatic cells, and their ...
arxiv
A mathematical framework for raw counts of single-cell RNA-seq data analysis [PDF]
arXiv, 2020 Single-cell RNA-seq data are challenging because of the sparseness of the read counts, the tiny expression of many relevant genes, and the variability in the efficiency of RNA extraction for different cells. We consider a simple probabilistic model for read counts, based on a negative binomial distribution for each gene, modified by a cell-dependent ...
arxiv
Apoptosis and necrosis of blood and milk polymorphonuclear leukocytes in early and midlactating healthy cows. [PDF]
, 2001 Increased milk somatic cell counts (SCC) are used as an indicator for bovine mastitis. During mastitis, polymorphonuclear leukocytes (PMN) become the predominant cell type.
Burvenich, Christian +3 more
core +4 more sources
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Detection and characterisation of Complement protein activity in bovine milk by bactericidal sequestration assay [PDF]
, 2015 Susan Maye is in receipt of a Teagasc Walsh Fellowship. Financial support by the Department of Agriculture, Food and the Marine is gratefully acknowledged.Copyright © Proprietors of Journal of Dairy Research 2015 (Institute of Food Research and the ...
Fitzgerald, Gerald F +3 more
core +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Recognizing Cancer via Somatic and Organic Evolution [PDF]
arXiv, 2014 The fitness of somatic cells of metazoan, the ability of proliferation and survival, depends on microenvironment. In somatic evolution, a mutated cell in a tissue clonally expands abnormally because of its high fitness as normal cells in a corresponding microenvironment.
arxiv
The relationship between cell size and cell fate in Volvox carteri [PDF]
, 1993 In Volvox carteri development, visibly asymmetric cleavage divisions set apart large embryonic cells that will become asexual reproductive cells (gonidia) from smaller cells that will produce terminally differentiated somatic cells. Three mechanisms have
Kirk, David L. +3 more
core +1 more source