Results 61 to 70 of about 76,323 (239)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Local and global contribution to selective and sustained attention

Current Research in Behavioral Sciences
This study introduces an innovative approach to measuring coherent motion thresholds under conditions that separately evaluate global and local visual contributions to sustained selective attention.
Victoria Geraldi Menegon, Natalia Máximo Alves Rocha, Leonardo Dutra Henriques, Marcelo Fernandes Costa   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Eye-brain connection: an altered profile of spatial attention in myopia

Frontiers in Neuroscience
BackgroundRefractive errors represent an important cause of visual impairment, impacting the quality of vision in billions of people across the globe.
Elie De Lestrange-Anginieur, Elie De Lestrange-Anginieur, Elie De Lestrange-Anginieur, Elie De Lestrange-Anginieur, Elie De Lestrange-Anginieur, Feng Pan, Feng Pan, Feng Pan, Feng Pan, Feng Pan, Benjamin Thompson, Benjamin Thompson, Kin Yau Wong   +12 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Cross-Modal Attention-Modulated Feature Enhancement Network for Visible-Infrared Ship Detection

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Ship detection is crucial for tasks, such as harbor dynamic surveillance and maritime traffic management, aiming to identify and locate ships. Multimodal object detection based on visible-infrared data is well suited for ship detection because it enables
Yaxin Lei, Wuxia Zhang, Xiaochen Niu, Hailong Ning, Xiaoqiang Lu   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Space-Time Block Coded Differential Spatial Modulation With Permutations

IEEE Transactions on Communications
Differential spatial modulation (DSM) is a noncoherent multi-antenna technique that conveys additional information by selecting transmit antennas. Space-time block coded DSM (STBC-DSM) combines DSM with STBC to achieve a transmit diversity order of two.
Ruey-Yi Wei, Chun-Yi Chen, Kai-Han Lin, Bo-Chun Lai   +3 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source