Results 81 to 90 of about 663,265 (283)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Numerical implementation of differential transformations method for integro-differential equations

International Journal of Computer Mathematics, 2010
Differential transformation (DT) is one of the numeric methods for solving differential equations. The advantage of this method is to transform the differential equation into algebraic ones. The aim of this article is to present a comparative study of the DT for solving of linear or nonlinear integro-differential equations.
openaire   +2 more sources

Solving Coupled Fractional Differential Equations Using Differential Transform Method.

Turkish Journal of Computer and Mathematics Education (TURCOMAT), 2021
This paper presents the solution of coupled equations which are of fractional order using differential transform method. In this paper we extend the scope of differential transform method to system of fractional differential equations so that we get the analytical solutions.
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

INITIAL VALUE PROBLEMS FOR NONLINEAR DIFFERENTIAL EQUATIONS SOLVED BY DIFFERENTIAL TRANSFORM METHOD [PDF]

The notion of differential transform was firstly introduced and applied to electrical circuits by J. Zhou, [4]. In the present paper we apply the differential transform method to solve initial values problems for nonlinear differential equations.
Flavia-Dalia FRUMOSU, Mircea CÎRNU
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

IMPROVING α-PARAMETERIZED DIFFERENTIAL TRANSFORM METHOD WITH DANDELION OPTIMIZER FOR SOLVING ORDINARY DIFFERENTIAL EQUATIONS

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
In this manuscript, we aim to address Ordinary Differential Equations (ODEs) by α-Parameterized Differential Transform Method (α-PDTM). Additionally, we seek to enhance the effectiveness of α-PDTM by incorporating the Dandelion Optimizer (DO).
Mustafa Raed Najeeb, Omar Saber Qasim
doaj   +1 more source

Modified Differential Transform Method for Two Singular Boundary Values Problems

Journal of Applied Mathematics, 2014
This paper deals with the two singular boundary values problems of second order. Two singular points are both boundary values points of the differential equation.
Yinwei Lin, Hsiang-Wen Tang, Cha’o-Kuang Chen   +2 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source