Results 131 to 140 of about 10,788 (221)

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Comparing Proton Transfer Reaction (PTR) and Adduct Ionization Mechanism (AIM) for the Study of Volatile Organic Compounds. [PDF]

Molecules
Avesani S, Bonato B, Simonetti V, Guerra S, Ravazzolo L, Gjinaj G, Dadda M, Castiello U.   +7 more
europepmc   +1 more source

Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing

Advanced Science, EarlyView.
Wearable sweat sensing relies not only on chemical detection but also on controlled biofluid management. This Review integrates sweat physiology, induction strategies, and microfluidic sampling architectures, demonstrating how flux, transport, and refreshment shape measurement reliability.
Soyoung Shin, Wei Gao
wiley   +1 more source

An anaerobic in vitro flow model for studying interactions at the gastrointestinal host-microbe interface. [PDF]

NPJ Biofilms Microbiomes
Bang LL, Pettersen JS, Høiland N, Rojek AM, Tornby DR, Møller-Jensen J, Justesen US, Pedersen RM, Andersen TE.   +8 more
europepmc   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

Avoidance of hydrogen sulfide is modulated by external and internal states in Caenorhabditis elegans. [PDF]

Elife
Pu L, Zhao L, Wang J, Deleuze C, Nilsson L, Henriksson J, Laurent P, Chen C.   +7 more
europepmc   +1 more source

Ultrafast Dynamics of Spin Current and Electron Temperature in Spintronic Terahertz Emitters

Advanced Science, EarlyView.
This work quantifies optical‐pump‐induced THz transmission variations to reveal electron and lattice temperature dynamics and presents time‐resolved THz spectral maps for sub‐picosecond analysis. A 63 ± 8 fs time lag between THz emission and laser excitation is identified, serving as an intrinsic parameter limiting the upper frequency of spintronic THz
Yifan Wang, Zuanming Jin, Miao Cai, Zhiqiang Lan, Zhenjie Ge, Zheng Feng, Wei Tan, Alexei V. Balakin, Alexander P. Shkurinov, Yan Peng, Yiming Zhu   +10 more
wiley   +1 more source

CFD Analyses of Density Gradients under Conditions of Supersonic Flow at Low Pressures. [PDF]

Sensors (Basel)
Bayer R, Bača P, Maxa J, Šabacká P, Binar T, Vyroubal P.   +5 more
europepmc   +1 more source

Integrating Automated Electrochemistry and High‐Throughput Characterization with Machine Learning to Explore Si─Ge─Sn Thin‐Film Lithium Battery Anodes

Advanced Energy Materials, Volume 15, Issue 11, March 18, 2025.
A closed‐loop, data‐driven approach facilitates the exploration of high‐performance Si─Ge─Sn alloys as promising fast‐charging battery anodes. Autonomous electrochemical experimentation using a scanning droplet cell is combined with real‐time optimization to efficiently navigate composition space.
Alexey Sanin, Jackson K. Flowers, Tobias H. Piotrowiak, Frederic Felsen, Leon Merker, Alfred Ludwig, Dominic Bresser, Helge Sören Stein   +7 more
wiley   +1 more source

Handling the heat: ocean acidification mitigates the effects of marine heatwaves on Posidonia oceanica seedlings. [PDF]

J Exp Bot
Pazzaglia J, Marín-Guirao L, Ambrosino L, Pes K, Costa M, Barrote I, Silva J, Procaccini G.   +7 more
europepmc   +1 more source