Results 191 to 200 of about 602,927 (312)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Barriers and opportunities in implementing adolescent sexual and reproductive health interventions in rural Guatemala: an exploratory descriptive study. [PDF]

Rev Panam Salud Publica
Chaparro Buitrago DC, Baumann A, Wahoush O, Gombay C, O'Shea T.   +4 more
europepmc   +1 more source

Differentiating "Integrative" from "Complementary", "Alternative" and "Unconventional": A Textual Analysis of the Terms and Meanings in the Peer-reviewed Literature

, 2015
Jeremy Y. Ng
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Integration of Conventional Sensors and Laser Doppler Vibrometry for Structural Modal Analysis: An Innovative Approach. [PDF]

Sensors (Basel)
Martínez López E, García-Fernández N, Pelayo F, García Diéguez M, Aenlle M.   +4 more
europepmc   +1 more source

Spatiotemporal Differentiation and Driving Factors of Urban–Rural Integration in Counties of Yangtze River Economic Belt [PDF]

Youming Dong, Long Li, Huang Xian-jin
openalex   +1 more source

Integration of a multi-omics stem cell differentiation dataset using a dynamical model

, 2023
Patrick R. van den Berg, Noémie M. L. P. Bérenger-Currias, Bogdan Budnik, Nikolai Slavov, Stefan Semrau   +4 more
openalex   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The actual and future role of molecular tests in thyroid pathology. [PDF]

Virchows Arch
Dettmer MS.
europepmc   +1 more source