Results 21 to 30 of about 23,295 (214)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Research on the Governance Dilemmas and Resilience Improvement in Old and Dilapidated Communities from the Perspective of Risk Inequality

open access: yesFengjing Yuanlin
ObjectiveAmid rapid urbanization and the increasing frequency of extreme climate events, urban systems are facing escalating systemic risks. As the fundamental unit of urban governance, community resilience — the capacity to withstand, adapt to, and ...
Yuefang RONG   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

DEVELOPMENT OF MEASUREMENT METHODOLOGIES IN METROLOGY FOR CELL BIOLOGY AND REGENERATIVE MEDICINE [PDF]

open access: yes, 2013
Aim of this thesis is the development of measurement methodologies in metrology for cell biology and regenerative medicine. Regenerative medicine is a novel branch of medicine based on the use of autologous stem cells and biocompatible medical devices to
Cardile, Diego   +2 more
core   +1 more source

Differentiable and Self-Auditing Transient Dynamics Solver for Ball Bearings: OpenBEARD Cross-Verified Against ADORE

open access: yesApplied Sciences
A transient multibody dynamics simulation of rolling-element bearings is the basis for the design of high-speed rotating machinery; however, the established solvers are proprietary, cannot be used with automatic differentiation, and offer no built-in ...
Xinlu Yu   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Choquet integrals in potential theory [PDF]

open access: yes, 1998
This is a survey of various applications of the notion of the Choquet integral to questions in Potential Theory, i.e. the integral of a function with respect to a non-additive set function on subsets of Euclidean n-space, capacity.
David R. Adams   +2 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Measure and Integration: A Concise Introduction to Real Ananysis

open access: yes, 2009
A uniquely accessible book for general measure and integration, emphasizing the real line, Euclidean space, and the underlying role of translation in real analysis.
Richardson, Leonard F.
core   +1 more source

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