Results 41 to 50 of about 398,379 (301)

The Conceptual LeanPPD Model [PDF]

, 2010
This paper is presenting the conceptual Lean Product and Process Development (LeanPPD) model which is a project funded by the EU-PF7. The project is addressing the needs of European manufacturing companies of a new model that goes beyond lean ...
Amaia Sopelana, Shehab, Essam, Sorli, Mikel, Flores, Myrna, Rahman Alam, Mike James-Moore, Ahmed Al-Ashaab, Myrna Flores, Sopelanad, Amaia, James-Moore, Mike, Alam, Rahman, Essam Shehab, Sopelana, Amaia, Mikel Sorli, Taisch, Marco, Marco Taisch, Al-Ashaab, Ahmed, Dragan Stokic, Stokic, Dragan   +18 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Striving for Difficulty as a Type of Perception of Life Situations

Вестник Московского университета. Серия 14: Психология
Background. Studying the types of perception of difficult life situations is a demanded task, since knowledge about the subject’s perception of ongoing events allows us to predict the characteristics of his interaction with the situation.
Ekaterina V. Bityutskaya , Marina I. Kunashenko   +1 more
doaj   +1 more source

Rational and Irrational Components of Difficult Life Situation Assessment by Adults (on the example of relatives of children who suffer from serious and life-threatening diseases)

, 2017
The article analyzes the role of rational and rational conscious components in difficult life situations assessment (DLS). Such indicators as meaningful goals, satisfaction of life process and its result, as well as the concept regarding life ...
Irina B. Dermanova, Alexander E. Tkachenko, Olga V. Alexandrova, Irina V. Kushnareva   +3 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Meaning-In-Life Orientations and Coping Strategies in HIV-Infected Women

Теоретическая и экспериментальная психология
Background. Medical and social challenges caused by the spread of the human immunodeficiency virus (HIV) are associated not only with the growing number of infected people but also with the need to find effective psychological support for adaptation to a
Olga V. Bulatova, Anastasia N. Tropina, Olga V. Krezhevskikh   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Personology of Difficult Life Situations: At the Intersection of Three Cultures [PDF]

Психология. Журнал Высшей школы экономики, 2019
The paper focuses on the analysis of phenomena involving the individual’s handling of difficult life situations (DLS). Handling DLS is interpreted in the context of ‘three cultures’: in the interrelation of the culture of scientific knowledge, the “ideofield of culture” and the culture of individual experience.
Vadim Petrovskiy, Ilya Shmelev
openaire   +1 more source

Psychological Well-Being of People Who Have Experienced a Difficult Life Situation: Affective and Cognitive Aspects [PDF]

, 2022
Анализируются отношения между когнитивно-аффективной сферой и уровнем психологического благополучия людей, переживших трудные жизненные ситуации. Рассмотрены основные виды трудных жизненных ситуаций и частота их встречаемости в исследуемой выборке ...
Denisova, E. G., Денисова, Е. Г.   +1 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source