Results 61 to 70 of about 2,024,869 (301)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Psychological resources of the personality in overcoming difficult life situations

Problems of Modern Psychology : Collection of research papers of Kamianets-Podilskyi National Ivan Ohiienko University, G. S. Kostiuk Institute of Psychology of the National Academy of Educational Sciences of Ukraine, 2018
Definitions of a difficult life situation and psychological resource in scientific psychological literature are analyzed. The main characteristics of a person’s feeling in difficult life situations are defined: the change of subjective feeling, personal changes of regressive nature which is characterized by self-centration; the organization of vital ...
I. V. Vashchenko, B. B. Ivanenko
openaire   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Assert Yourself! evaluating the performance of an HIV prevention intervention [PDF]

, 1999
Duration: November 1996 - June 2012 CHAPS is a collaborative programme of HIV health promotion for gay men and bisexual men living in England. It is co-ordinated by Terrence Higgins Trust on behalf of a range of project partners, including Sigma ...
Boxford, R, Hickson, F
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Family as a resource for overcoming difficult life situations in children affected by hostilities

Социальная психология и общество
Context and relevance. Children who have suffered to some extent as a result of hostilities, including those living in the territories directly affected by hostilities, experience the psychological consequences, such as maladjustment ...
O.A. Ulyanina, O.L. Yurchuk, L.A. Aleksandrova, E.A. Nikiforova, K.A. Faizullina   +4 more
doaj   +1 more source

THE NEED FOR SOCIAL SUPPORT AND THE FUNCTIONING OF INDIVIDUALS IN A HEALTH-LIMITING CONDITION

Humanities and Social Sciences, 2020
Introduction: Negative and difficult life experiences, and stressful situations that an individual may face, affects not only those who experience such situations but also their family and friends.
Lilia SUCHOCKA, Eleonora KRAJEWSKA, Małgorzata PASEK   +2 more
doaj   +1 more source

Aporia and the Implications for the Intuitive Knowledge of Children | Blog of the APA [PDF]

, 2018
The compass we use to navigate life needs to be cultivated from an early age. My sense is that the arts, including Plato’s dialogues cultivate our navigational sense. It does not tell us rationally what is good or what is bad.
Tillmanns, Maria daVenza
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

I. A. Ilyin About Experience of Difficult life Situations [PDF]

Humanitarian: actual problems of the humanities and education, 2020
Introduction. In a context of the psychological analysis of the scientific heritage of the famous Russian philosopher I. A. Ilyin, the problem of experiencing difficultness and critical life situations is considered. He believed that such situations are integral companions of human life. Therefore, a person should be ready to meet them.
openaire   +1 more source