Results 121 to 130 of about 1,409,166 (297)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Cohort change, diffusion, and support for gender egalitarianism in cross-national perspective

Demographic Research, 2011
Arguments about the spread of gender egalitarian values through a population highlight several sources of change. First, structural arguments point to increases in the proportion of women with high education, jobs with good pay, commitment to careers ...
Fred Pampel
doaj  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Radiomics prediction of MGMT promoter methylation in adult diffuse gliomas: a combination of structural MRI, DCE, and DTI

Frontiers in Neurology
PurposeTo assess the predictive value of radiomics features extracted from structural MRI, dynamic contrast enhanced (DCE), and diffusion tensor imaging (DTI) in detecting O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in patients ...
Yuying Liu, Yuying Liu, Zhengyang Zhu, Jianan Zhou, Han Wang, Huiquan Yang, Jinfeng Yin, Yitong Wang, Xin Li, Futao Chen, Qian Li, Zhuoru Jiang, Xi Wu, Danni Ge, Yi Zhang, Xin Zhang, Bing Zhang, Bing Zhang, Bing Zhang, Bing Zhang, Bing Zhang   +20 more
doaj   +1 more source

Efficient pricing of interest rate derivatives under a sticky diffusion

Journal of Computational and Applied Mathematics
The paper proposes a lattice-based approximation for pricing bonds and interest-sensitive claims when short-term interest rates fluctuate according to an Ornstein-Uhlenbeck process with the sticky reflecting boundary at zero. The framework is of particular interest when central banks adopt zero interest rate policies, e.g., the US monetary policy ...
Massimo Costabile, Emilio Russo, Fabio Viviano   +2 more
openaire   +3 more sources

Diffuse matter in galaxies /

, 1983
"Published in cooperation with NATO Scientific Affairs Division.""Proceedings of the NATO Advanced Study Institute on Diffuse Matter in Galaxies, Cargèse, France, September 1-16, 1982"--Verso t.p.Includes bibliographies and ...
Audouze, Jean(viaf)29512741edt, North Atlantic treaty organization. Scientific affairs division, NATO advanced study institute on diffuse matter in galaxies01/09/1982-16/09/1982Cargèse, France   +2 more
core  

Family tracing: In whose interests?

, 1994
This article is based on research commissioned by Save the Children Fund (SCF) into five family-tracing programmes in five African countries. The author describes the stages involved in tracing the families of children, and highlights the efforts that ...
Bonnerjea, Lucy
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Influence of organism’s individual resistance to hypoxia on the humoral immunity at the modeled experimental diffuse cardiosclerosis

Journal of Education, Health and Sport, 2015
Saturska H. S., Bondarenko Yu. I., Potikha N. Ya. Влияние индивидуальной резистентности организма к гипоксии на состояние гуморального иммунитета при смоделированном экспериментальном диффузном кардиосклерозе = Influence of organism’s individual ...
Hanna Stepanivna Saturska, Yurii Ivanovych Bondarenko, Natalia Yaroslavivna Potikha   +2 more
doaj   +2 more sources