Results 51 to 60 of about 333,521 (317)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Separation Iron(III)-Manganese(II) via Supported Liquid Membrane Technology in the Treatment of Spent Alkaline Batteries

Membranes, 2021
In this paper, the transport of iron(III) from iron(III)-manganese(II)-hydrochloric acid mixed solutions, coming from the treatment of spent alkaline batteries through a flat-sheet supported liquid membrane, is investigated (the carrier phase being of ...
Francisco J. Alguacil, Félix A. Lopez
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Active diffusion and advection in Drosophila oocytes result from the interplay of actin and microtubules

Nature Communications, 2017
Intracellular transport is facilitated by a combination of processes including directed transport, advection and diffusion. Here the authors microscopically characterise the dynamics of the Drosophila oocyte and find distinct contributions of ...
Maik Drechsler, Fabio Giavazzi, Roberto Cerbino, Isabel M. Palacios   +3 more
doaj   +1 more source

Reduction of dimensionality in Karyopherinβ1 mediated transport on FG domains [PDF]

, 2014
Many molecular transport processes in living cells proceed by facilitated diffusion in two dimensions instead of three, but how this process works remains poorly understood.
Schleicher, Kai D.
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Diffusion Approximation to Neutron Transport Equation with First Kind of Chebyshev Polynomials

Süleyman Demirel Üniversitesi Fen-Edebiyat Fakültesi Fen Dergisi, 2015
: The first kind of Chebyshev polynomials are used for the series expansion of the neutron angular flux in neutron transport theory. The first order approximation known as the diffusion approximation is applied to one-dimensional neutron transport ...
Ökkeş EGE, Hakan ÖZTÜRK, Ahmet BÜLBÜL   +2 more
doaj  

Study of Hydrodynamic Dispersion Laws in Homogeneous and Heterogeneous Soil

Renmin Zhujiang, 2022
To investigate the general laws of solute transport in homogeneous and heterogeneous soil,this study conducts column experiments in the laboratory to observe and monitor hydrodynamic dispersion under different conditions.The measured breakthrough curves ...
WANG Da, ZHUANG Luwen, LIN Kairong, FENG Shangchao   +3 more
doaj  

Modeling amperometric biosensors based on allosteric enzymes

Computational Science and Techniques, 2013
Computational modeling of a biosensor with allosteric enzyme layer was investigated in this study. The operation of the biosensor is modeled using non-stationary reaction-diffusion equations.
Liutauras Ričkus
doaj   +1 more source