Results 201 to 210 of about 179,449 (293)

Multimodal Chromatography in the Downstream Processing of mAb‐Based Products: Mechanisms, Strategies, and Applications

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Multimodal chromatography has emerged as a powerful tool for the purification of monoclonal antibodies (mAbs) and their derivatives—including antibody fragments (Fabs), Fc‐fusions, bispecific (BsAb), and antibody–drug conjugates (ADCs)—offering enhanced selectivity through the integration of ionic, hydrophobic, hydrogen‐bonding, and π–π ...
Amin Javidanbardan   +4 more
wiley   +1 more source

Performance of large virus removal filters during AAV processing: Influence of flux and process disruptions

open access: yesBiotechnology Progress, EarlyView.
Abstract As adeno‐associated viral vectors (AAV) continue to advance through the clinical pipeline, effective downstream purification strategies must be developed to ensure bulk drug purity and safety. AAV are produced within mammalian cells, bringing forth risks associated with viral contamination.
Akshay S. Chaubal   +5 more
wiley   +1 more source

Metasurface Enhanced Photothermal Cement Foam for Robust and High‐Throughput Seawater Desalination

open access: yesCarbon Energy, EarlyView.
Schematic of 3D metasurface‐enhanced cement foam for robust and high‐throughput seawater desalination. This study presents a cement‐based solar evaporator (CSE) fabricated in one step via viscoelastic lithography with simple negative pressure. In addition to boosting solar‐to‐vapor conversion efficiency via excellent light‐harvesting capacity, the ...
Jianjun Guo   +4 more
wiley   +1 more source

Integrating computational fluid dynamics into organ-on-chip systems: a glioblastoma-centred design and validation framework. [PDF]

open access: yesFront Bioeng Biotechnol
Taleban H   +6 more
europepmc   +1 more source

Three‐Dimensional Highly Thermally Conductive Graphene Blocks by Multiscale Blending and Multistage Pressure Induction

open access: yesCarbon Energy, EarlyView.
An expandable‐thickness graphene block (GPB) with high thermal conductivity synthesized through multiscale blending and multistage pressure induction (MBP) achieves a record thickness of 12.1 mm, which is more than 10 times that of existing graphene materials. The maximum thermal diffusion ability of GPB‐MBP reaches 6.3 W/K, which offers a new approach
Liyu Zhang   +9 more
wiley   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

open access: yesChemistry – A European Journal, EarlyView.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

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