Results 111 to 120 of about 29,508,989 (334)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Ultrafast Diffusion Modeling via the Riemann–Liouville Nonlocal Structural Derivative and Its Application in Porous Media

Fractal and Fractional
Ultrafast diffusion disperses faster than super-diffusion, and this has been proven by several theoretical and experimental investigations. The mean square displacement of ultrafast diffusion grows exponentially, which provides a significant challenge ...
Wei Xu, Hui Liu, Lijuan Chen, Yongtao Zhou   +3 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Modeling the Diffusion of Private Pension Provision

Scientific Annals of Economics and Business, 2018
The purpose of this paper is threefold: to adapt the innovation diffusion models to describe and predict the diffusion of private pension provision; to evaluate the suitability of diffusion models based on the historical data from the Romanian and ...
Yakymova Larysa
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Diffusion of urea through membranes [PDF]

, 2006
Non-invasive real time monitoring of topical drug delivery is an important subject of dermatopharmaceutical research. It has been proved that Fourier transform infrared attenuated total refection (FTIR-ATR) is a versatile technique to study drug ...
Neubert, Reinhard, Günther, Ulrike, Wartewig, Siegfried, Hartmann, Marcus   +3 more
core   +1 more source

Opponent Modeling Based on Cross-Attention Diffusion Model [PDF]

Jisuanji gongcheng
As a key technology in multi-agent game confrontation, opponent modeling aims to learn the behavior of the opponent to reduce the uncertainty of the environment and facilitate decision-making.
HE Mingyan, LI Siyuan, LIU Peng, HUANG Jianhua
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Diffusion Models in De Novo Drug Design [PDF]

Journal of Chemical Information and Modeling
Diffusion models have emerged as powerful tools for molecular generation, particularly in the context of 3D molecular structures. Inspired by nonequilibrium statistical physics, these models can generate 3D molecular structures with specific properties ...
Amira Alakhdar, Barnabás Póczos, Newell Washburn   +2 more
semanticscholar   +1 more source

Ambigram Generation by a Diffusion Model

, 2023
Ambigrams are graphical letter designs that can be read not only from the original direction but also from a rotated direction (especially with 180 degrees). Designing ambigrams is difficult even for human experts because keeping their dual readability from both directions is often difficult. This paper proposes an ambigram generation model.
Takahiro Shirakawa, Seiichi Uchida
openaire   +2 more sources