Results 91 to 100 of about 1,683,867 (302)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Implementation of anatomical navigators for real time motion correction in diffusion tensor imaging [PDF]

, 2012
Includes bibliographical references.Prospective motion correction methods using an optical system, diffusion-weighted prospective acquisition correction, or a free induction decay navigator have recently been applied to correct for motion in diffusion ...
Alhamud, Alkathafi Ali
core   +1 more source

Optimization of Diffusion Spectrum Imaging and Q-Ball Imaging on Clinical Mri System

, 2009
Mapping complex crossing fibers using diffusion MRI techniques requires adequate angular precision and accuracy. Beyond diffusion tensor imaging ( DTI), high angular resolution sampling schemes such as diffusion spectrum imaging (DSI) and q-ball imaging (
KUO, LI-WEI;CHEN, JYH-HORNG;TSENG, WEN-YIH, 郭立威;陳志宏;曾文毅   +1 more
core   +1 more source

Subchronic memantine induced concurrent functional disconnectivity and altered ultra-structural tissue integrity in the rodent brain: revealed by multimodal MRI [PDF]

, 2013
Background An effective NMDA antagonist imaging model may find key utility in advancing schizophrenia drug discovery research. We investigated effects of subchronic treatment with the NMDA antagonist memantine by using behavioural observation and ...
Ver Donck, L., Van der Linden, A, Giugliano, M., Sijbers, J., Sijbers, J, Wuyts, K, Sekar, S, Couto, J, Ver Donck, L, Willems, R, Mackie, C., Steckler, T, Couto, J., Van Der Linden, A., Willems, R., Jonckers, Elisabeth, Jonckers, E., Veraart, J, Van Auderkerke, J, Steckler, T., Giugliano, M, Veraart, J., Wuyts, K., Mackie, C, Van Audekerke, J., Dedeurwaerdere, S., Verhoye, M, Verhoye, M., De Deurwaerdere, S, Sekar, S.   +29 more
core   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Diffusion-Weighted MRI and apparent

The Egyptian Journal of Radiology and Nuclear Medicine, 2016
The purpose of this study was to evaluate use of Diffusion-Weighted MRI (DWI) and apparent diffusion coefficient value (ADC) in differentiation of intra-medullary spinal cord masses (IMSCM).
Doaa Ibrahim Hasan, Mohamed H. Abowarda, Mahmoud M. Taha   +2 more
doaj   +1 more source

Automated quality control for within and between studies diffusion MRI data using a non-parametric framework for movement and distortion correction [PDF]

, 2018
Diffusion MRI data can be affected by hardware and subject-related artefacts that can adversely affect downstream analyses. Therefore, automated quality control (QC) is of great importance, especially in large population studies where visual QC is not ...
Cottaar, M, Suri, Sana, Fitzgibbon, SP, Bastiani, M, Suri, S, Jbabdi, S, Cottaar, Michiel, Alfaro-Almagro, Fidel, Alfaro-Almagro, F, Jbabdi, Saad, Sotiropoulos, SN, Andersson, Jesper, Bastiani, Matteo, Sotiropoulos, Stamatios N., Fitzgibbon, Sean P., Andersson, J   +15 more
core   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Diffusion, confusion and functional MRI

NeuroImage, 2012
Diffusion MRI has been introduced in 1985 and has had a very successful life on its own. While it has become a standard for imaging stroke and white matter disorders, the borders between diffusion MRI and the general field of fMRI have always remained fuzzy.
openaire   +3 more sources

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source