Results 111 to 120 of about 1,989,896 (322)

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

open access: yesMolecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker   +3 more
wiley   +1 more source

Diffusion Processes on Manifolds

open access: yes, 2008
This is an informal introduction to stochastic analysis on both Riemannian and Lorentzian manifolds. We review the basics underlying the construction of diffusions on manifolds, highlighting the important differences between the Riemannian and Lorentzian cases. We also discuss a few recent applications which range from biophysics to cosmology.
Debbasch, Fabrice, Chevalier, Claire
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

open access: yesFEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang   +6 more
wiley   +1 more source

A birth, death, and diffusion process

open access: yesJournal of Mathematical Analysis and Applications, 1963
AbstractThis paper treats of a model of a population whose individuals diffuse on a line according to the usual Brownian motion scheme (with constant diffusion coefficient σ22) and at the same time undergo births and deaths with constant rates λ and μ respectively.
S.R Adke, J. E. Moyal
openaire   +3 more sources

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