Results 111 to 120 of about 6,587,940 (291)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Anomalous diffusion and ergodicity breaking in heterogeneous diffusion processes
New Journal of Physics, 2013 We demonstrate the non-ergodicity of a simple Markovian stochastic process with space-dependent diffusion coefficient D ( x ). For power-law forms D ( x ) ≃ | x | ^α , this process yields anomalous diffusion of the form 〈 x ^2 ( t )〉 ≃ t ^2/(2− ^α ...
Andrey G Cherstvy +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Why cannot long-term cascade be predicted? Exploring temporal dynamics in information diffusion processes. [PDF]
R Soc Open Sci, 2021 Cao RM, Liu XF, Xu XK.
europepmc +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Effective diffusion tensor computed by homogenization [PDF]
, 2013 The convergence of the long-time apparent diffusion tensor of diffusion magnetic resonance imaging (dMRI) to the effective diffusion tensor obtained by mathematical homogenization theory was considered for two-compartment geometric models containing non ...
Grebenkov, Denis +4 more
core +1 more source
Kinetic control concept for the diffusion processes of paracetamol active molecules across affinity polymer membranes from acidic solutions. [PDF]
BMC Chem, 2022 Tarhouchi S +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source