Results 41 to 50 of about 131,358 (264)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Diffusion-weighted imaging and diffusion-weighted whole-body imaging with background body signal suppression for characterizing esophageal cancer: a case report

International Medical Case Reports Journal, 2013
Minoru Tomizawa,1 Fuminobu Shinozaki,2 Aika Ozaki,2 Akira Baba,2 Yoshiya Fukamizu,2 Futoshi Matsunaga,2 Takao Sugiyama,3 Shigenori Yamamoto,4 Makoto Sueishi,3 Takanobu Yoshida51Department of Gastroenterology, 2Department of Radiology, 3Department of ...
Tomizawa M, Shinozaki F, Ozaki A, Baba A, Fukamizu Y, Matsunaga F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T   +9 more
doaj  

Diagnostic Comparison of MRI Sequences for Assessing Myometrial Invasion in Endometrial Cancer: A 1.5T MRI Study

Hitit Medical Journal
Objective: To compare the diagnostic accuracy of T2-weighted, dynamic contrast-enhanced imaging, and diffusion-weighted imaging in assessing myometrial invasion depth in endometrial cancer and to determine if any sequence performs better.
Abdusselim Adil Peker, Ahmet Akçay
doaj   +1 more source

Role of diffusion weighted imaging in characteriza

The Egyptian Journal of Radiology and Nuclear Medicine, 2016
Purpose: The purpose of the study was to show the value of combination of conventional MRI with DWI to raise the sensitivity and specificity considering the differentiation between pancreatic benign and malignant lesions.
Eman Salah Mohammed Abdallah, Mohamed Ibrahim Mahmoud Ali, Maryse Yousef Awadallah, Hamed Samir Hamed El Ghawabi   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Scedosporium apiospermum endophthalmitis: diffusion-weighted imaging in detecting subchoroidal abscess

Clinical Ophthalmology, 2012
Sandeep Bhuta, Charlie Chia-Tsong Hsu, Gigi Nga Chi KwanGriffith University, School of Medicine, Department of Medical Imaging, Gold Coast Hospital, Southport, Gold Coast, QLD, AustraliaPurpose: To describe the imaging appearance of Scedosporium ...
Kwan GN, Hsu CC, Bhuta S
doaj  

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Diffusion weighted imaging and diffusion kurtosis imaging in abdominal oncological setting: why and when

Infectious Agents and Cancer, 2022
This article provides an overview of diffusion kurtosis (DKI) imaging in abdominal oncology. DKI allows for more data on tissue structures than the conventional diffusion model (DWI).
Vincenza Granata, Roberta Fusco, Andrea Belli, Ginevra Danti, Eleonora Bicci, Carmen Cutolo, Antonella Petrillo, Francesco Izzo   +7 more
doaj   +1 more source

APT weighted imaging in diffuse gliomas

BJR|Open, 2023
Amide proton transfer-weighted (APTw) imaging is a non-invasive molecular MRI technique with a wide range of applications in neuroradiology and particularly neuro-oncology imaging. More than 15 years of pre-clinical experiments and clinical studies have demonstrated that APTw metrics are reproducible and reliable, leading to large-scale clinical ...
Lucia Nichelli, Moritz Zaiss, Stefano Casagranda   +2 more
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source