Results 191 to 200 of about 689,914 (249)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Effects of reheating methods on oxidation and digestibility characteristics of precooked braised chicken during <i>in vitro</i> digestion. [PDF]

Food Chem X
Li J, Shi H, Bai Y, Wang Y, Cao L, Liu S, Zhao D, Meng S, Bai Y.   +8 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Effects of different cooking methods on processing and digestive properties of broiler chicken breast. [PDF]

Poult Sci
Yang C, Ma C, Jin L, Chen L, Xing L, Zhang W.   +5 more
europepmc   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Machine learning and adaptive control for optimizing MSW-algal biomass anaerobic co-digestion. [PDF]

Sci Rep
Tiwari MD, Dhengare SW, Yenurkar GK, Bhagat RM, Pande PB, S A.   +5 more
europepmc   +1 more source

Enhanced Proteomics Analysis with a Novel Recombinant Chymotrypsin Analogue Engineered for High Cleavage Specificity. [PDF]

J Proteome Res
Adoni KR, Ditcham JE, González Rivera AK, Charlton GH, Saveliev SV, Thalassinos K, Zenezini Chiozzi R.   +6 more
europepmc   +1 more source

Protocol for isolation of lipid-laden hepatocytes from high-fat diet-fed and metabolically challenged mice. [PDF]

STAR Protoc
Ponnusamy T, Natarajaseenivasan K, Shanmughapriya S.   +2 more
europepmc   +1 more source

Exploring the effects of dietary starch digestion kinetics on net energy utilization in peak laying hens. [PDF]

Poult Sci
Zhu H, Fu M, Ding H, Liang J, Chen X, Qin G, Pan L, Bao N, Zhao Y.   +8 more
europepmc   +1 more source