Results 51 to 60 of about 253,146 (176)

Acceleration of catalyst discovery with easy, fast, and reproducible computational alchemy

open access: yesInternational Journal of Quantum Chemistry, 2020
The expense of quantum chemistry calculations significantly hinders the search for novel catalysts. Here, we provide a tutorial for using an easy and highly cost-efficient calculation scheme called alchemical perturbation density functional theory (APDFT)
Charles D Griego, J. Kitchin, J. Keith
semanticscholar   +1 more source

Ex Nihilo (2017-2018) [PDF]

open access: yes, 2017
Table of Contents: Sex is About Power: Dissecting Pornography’s Role in the Sexual Language Game / by Hitaxhe Kupa; The University of Pennsylvania (p.
Undergraduate Philosophy Association (Austin, Tex.)
core   +1 more source

Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design

open access: yesAdvanced Science, Volume 12, Issue 23, June 20, 2025.
In this study, a computational pipeline is developed to systematically evaluate the conformational stability, disulfide bond reduction state, and aggregation and degradation tendencies of an anticancer VHH‐Fc fusion antibody. Based on the mechanistic insights, antibody variants with enhanced stability and increased yield are successfully designed. This
Yuan Fang   +10 more
wiley   +1 more source

Bioprinted Patient‐Derived Organoid Arrays Capture Intrinsic and Extrinsic Tumor Features for Advanced Personalized Medicine

open access: yesAdvanced Science, Volume 12, Issue 20, May 29, 2025.
An embedded bioprinting enabled‐arrayed patient‐derived organoids (Eba‐PDO) platform that replicates intrinsic and extrinsic tumor characteristics is introduced. Eba‐PDOs more accurately mimic tissue than standard PDOs (Std‐PDOs) due to maturation in the tumor microenvironment.
Jonghyeuk Han   +15 more
wiley   +1 more source

Anti‐Inflammatory Macrophage‐Derived Exosomes Modified With Self‐Antigen Peptides for Treatment of Experimental Autoimmune Encephalomyelitis

open access: yesAdvanced Science, Volume 12, Issue 13, April 3, 2025.
Anti‐inflammatory macrophage‐derived exosomes modified with selfantigen peptides are developed to induce antigen‐specific immune tolerance. These exosomes demonstrate prophylactic effects in experimental autoimmune encephalomyelitis. Abstract Current treatments for autoimmune diseases often involve broad‐acting immunosuppressants, which carry risks ...
Qiaoyun Li   +5 more
wiley   +1 more source

REM Sleep and the emotional brain [PDF]

open access: yes, 2012
Thesis (S.M. in Science Writing)--Massachusetts Institute of Technology, Dept. of Humanities, Graduate Program in Science Writing, 2012.Cataloged from PDF version of thesis.Includes bibliographical references (p. 43-47).Sleep and emotion have been linked
Beck, Taylor McGowin
core  

Durable Muscle Extracellular Matrix Engineered with Adhesive Phenolic Moieties for Effective Skeletal Muscle Regeneration in Muscle Atrophy

open access: yesAdvanced Healthcare Materials, Volume 13, Issue 32, December 27, 2024.
Phenolic adhesive muscle extracellular matrix hydrogels with improved tissue adhesion, mechanical properties, and muscle‐specific cues are developed to treat muscle loss. These hydrogels facilitate muscle regeneration in disuse‐induced muscle atrophy and sarcopenia mouse models by generating enduring muscle‐like microenvironments for rejuvenating ...
Soojeong Choi   +5 more
wiley   +1 more source

Assessment, feedback and the alchemy of learning

open access: yesMedical Education, 2018
Models of sound assessment practices increasingly emphasise assessment's formative role. As a result, assessment must not only support sound judgements about learner competence, but also generate meaningful feedback to guide learning.
C. Watling, S. Ginsburg
semanticscholar   +1 more source

Painting Things [PDF]

open access: yes, 2016
This essay traces the evolution of my practice-driven, reflexive investigation surrounding the iterative process of painting things. The body of work described in the essay follows the chronology of my studio production as I explore methods of ...

core   +1 more source

High‐Efficiency, Prevascularization‐Free Macroencapsulation System for Subcutaneous Transplantation of Pancreatic Islets for Enhanced Diabetes Treatment

open access: yesAdvanced Materials, Volume 36, Issue 50, December 12, 2024.
A high‐efficiency, prevascularization‐free macroencapsulation system for the subcutaneous transplantation of pancreatic islets is developed. This novel system demonstrates excellent long‐term blood glucose control at the subcutaneous site, even with the transplantation of ≈250 IEQ of islets.
Seunggyu Jeon   +5 more
wiley   +1 more source

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